Elastatinal 

Elastatinal is a potent and competitive inhibitor of elastase, with a K_i of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease^[1][2][3][4].

Elastatinal inhibits the binding of acetyl-alanyl-alanyl-alanine pnitroanilide and acetyl-alanyl-alanyl-alanine methyl ester to elastase, with K_is of 0.24 μM and 0.21 μM, respectively^[1].
Elastatinal (5-20 μM) suppresses the enhanced osteoclast differentiation by neutrophils^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

512.56

C₂₁H₃₆N₈O₇

51798-45-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Umezawa H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 1976;45:678-95.  [Content Brief]

  [2]. Feinstein G, et, al. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13;429(3):925-32.  [Content Brief]

  [3]. Sugisaki R, et, al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020 Mar;132:115216.  [Content Brief]

  [4]. Vidhya R, et, al. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol Immunotoxicol. 2020 Oct;42(5):423-435.  [Content Brief]