1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Enclomiphene hydrochloride

Enclomiphene hydrochloride  (Synonyms: (E)-Clomiphene hydrochloride; trans-Clomiphene hydrochloride; Enclomifene hydrochloride)

目录号: HY-118861B
产品使用指南

Enclomiphene ((E)-Clomiphene) hydrochloride 是一种有效的、可口服的非甾体雌激素受体 (estrogen receptor) 拮抗剂,具有抗雌激素作用。Enclomiphene hydrochloride 可用于卵巢功能障碍、睾酮缺乏、男性性腺功能减退症和 type 2 型糖尿病的相关研究。

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Enclomiphene hydrochloride Chemical Structure

Enclomiphene hydrochloride Chemical Structure

CAS No. : 14158-65-7

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Enclomiphene hydrochloride 的其他形式现货产品:

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  • 生物活性

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生物活性

Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes[1].

体外研究
(In Vitro)

Enclomiphene hydrochloride (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion[2].
Enclomiphene hydrochloride (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes[3].
Enclomiphene hydrochloride (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Enclomiphene hydrochloride (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene hydrochloride (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 21 days-old Charles River male rats[5]
Dosage: 0.25 and 0.5 mg/animal, daily for 24 days.
Administration: Subcutaneous injection
Result: Decreased LH and testosterone levels in the serum.
Animal Model: OVX (ovariectomy) rat model[6]
Dosage: 0.03, 1, and 3 mg/kg, daily for 90 days.
Administration: Oral adminstration
Result: Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
Clinical Trial
分子量

442.42

Formula

C26H29Cl2NO

CAS 号
中文名称

恩氯米芬盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Enclomiphene hydrochloride 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Enclomiphene hydrochloride
目录号:
HY-118861B
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