2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. ADC Antibody Nectin-4
  4. Enfortumab

Enfortumab  (Synonyms: 恩诺单抗)

目录号: HY-P99016 纯度: 99.90%
COA 技术支持

Enfortumab 是一种人源化的抗 Nectin-4 抗体，可以与高效微管破坏剂 MMAE (HY-15162) 偶联生成抗体-药物偶联物 (ADC) Enfortumab vedotin-ejfv (HY-P99016A)。Enfortumab 可用于局部晚期和转移性尿路上皮癌的研究。

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CAS No. : 1448664-46-7

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1 mg ￥2800
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Customer Review

Other Forms of Enfortumab:

Enfortumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enfortumab is a humanized derived anti-Nectin-4 antibody that can be conjugated with the highly efficient microtubule disruptor MMAE (HY-15162) to generate the antibody drug conjugate (ADC) Enfortumab vedotin-ejfv (HY-P99016A). Enfortumab can be used for the study of locally advanced and metastatic urothelial carcinoma[1][2].
同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

Nectin-4
体外研究
(In Vitro)

Enfortumab Vedotin 是一种抗体-药物偶联物 (ADC)，由靶向 nectin-4 的人源化单克隆抗体和 Monomethyl auristatin E (HY-15162) 组成。Nectin-4 在尿路上皮癌中高表达，MMAE 是一种微管破坏剂。Enfortumab Vedotin 通过结合nectin-4，将MMAE递送至肿瘤细胞内部，从而抑制细胞微管的形成，导致细胞周期停滞和细胞凋亡[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enfortumab 相关抗体:
Clinical Trial
基因 ID

81607  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.44 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

恩诺单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human Nectin-4 His can bind Enfortumab. The EC50 for this effect is 3.846 ng/mL.
纯度 & 产品资料

纯度: 99.90%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Enfortumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enfortumab1448664-46-7恩诺单抗ADC AntibodyNectin-4Anti-Nectin-4 antibodyADCurothelial carcinomaInhibitorinhibitorinhibit

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