Eptapirone fumarate  (Synonyms: F 11440 fumarate)

Eptapirone fumarate (F11440 fumarate) is a potent, selective and orally active 5-HT_1A receptor agonist (pK_i = 8.33). Eptapirone fumarate can inhibit cAMP production. Eptapirone fumarate can reduce 5-HT levels and increase corticosterone levels. Eptapirone fumarate shows potent anxiolytic and antidepressant potential. Eptapirone fumarate can be used for the research of neurological disease, such as anxiety and depression^[1].

Eptapirone fumarate 降低 HeLa 细胞中 Forskolin (HY-15371) 诱导的 cAMP 产生，其 pEC₅₀ 值为 6.8^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eptapirone fumarate (0.16-640 mg/kg，口服，单剂量) 在焦虑和抑郁大鼠模型中产生抗焦虑和抗抑郁样作用^[1]。
Eptapirone fumarate (0.01-0.63 mg/kg，腹腔注射) 可降低大鼠腹侧海马微透析液中的 5-HT 水平^[1]。
Eptapirone fumarate (0.0063-160 mg/kg，口服) 可升高大鼠的血浆皮质酮水平^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

461.47

C₂₀H₂₇N₇O₆

179756-85-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Koek W, et al. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. J Pharmacol Exp Ther. 1998 Oct;287(1):266-83.  [Content Brief]