2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. Evybactin

Evybactin 是 DNA 旋转酶 的抑制剂。Evybactin 是结核杆菌的选择性抑制剂，MIC 值为 0.25 µg/mL。Evybactin 是第一个被发现的具有这种选择性机制的抗菌化合物。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Evybactin

Evybactin Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Evybactin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity[1].

IC50 & Target

IC50: 1 μM (DNA cleavage)[1]
体外研究
(In Vitro)

Evybactin (0-1000 µg/mL; 24 h) inhibits Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL[1].
Evybactin (100 µM; 30 min) induces DNA cleavage with an IC50 value of 1 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Evybactin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, FaDu and HEK293 cell lines
Concentration: 0-1000 µg/mL
Incubation Time: 24 hours
Result: Showed no toxicity against HepG2, FaDu and HEK293 human cells with IC50s ＞128 µg/mL.
体内研究
(In Vivo)

Evybactin (25-100 mg/kg; i.p. once) effectively inhibits E. coli infection in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with E. coli infection[1]
Dosage: 25 and 100 mg/kg
Administration: Intraperitoneal injection; 25 and 100 mg/kg once
Result: Showed significant efficacy with a single dose of 25 mg/kg, and protected mice from infection with a single dose of 100 mg/kg, whereas 83% of untreated control animals died in 24 hours.
分子量

1488.52

Formula

C64H89N21O21
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Evybactin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EvybactinBacterialDNA/RNA SynthesishydrophilicBacAPhotorhabdus noenieputensisantibioticantimicrobialDNA cleavageInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Evybactin
目录号：
HY-P3473
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z