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  3. FLDP-5

FLDP-5 是一种具有血脑屏障透过性的姜黄素类似物。FLDP-5 可诱导活性氧 (ROS) 的产生、DNA 损伤和细胞周期 S 期阻滞。FLDP-5 对 LN-18 细胞具有抗增殖和抗迁移活性,具有很强的肿瘤抑制作用。

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FLDP-5 Chemical Structure

FLDP-5 Chemical Structure

CAS No. : 950665-12-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells[1].

体外研究
(In Vitro)

FLDP-5 (0-20 μM; 24 h) has cytotoxicity on human glioblastoma multiforme (GBM) LN-18 cells and HBEC-5i[1].
FLDP-5 (2.5 μM; 0-6 h) induces superoxide and hydrogen peroxide in LN-18 cell death[1].
FLDP-5 (2.5 μM; 0-4 h) induces DNA damage with a time-dependent manner in LN-18 cells[1].
FLDP-5 (1.25 and 2.5 μM; 24 and 48 h) potentiates anti-migration effects in LN-18 cells[1].
FLDP-5 (1.25 and 2.5 μM; 24 h) reduces the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner[1].
FLDP-5 (0.625 and 1.25 μM; 24 h) induces arrest in S phase in a concentration-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: LN-18 and HBEC-5i cells
Concentration: 0-20 μM
Incubation Time: 24 h
Result: Exhibited cytotoxicity on human GBM LN-18 cells and HBEC-5i with IC50s of 2.4 μM and 5.6 μM.

Cell Migration Assay [1]

Cell Line: LN-18 cells
Concentration: 1.25 and 2.5 μM
Incubation Time: 24 and 48 h
Result: Potentiated anti-migration effects in LN-18 cells with wound closure of 56.43% ± 6.28 and 3.17% ± 0.71 at 1.25 μM and 2.5 μM (48 h), respectively.

Cell Invasion Assay[1]

Cell Line: LN-18 cells
Concentration: 1.25 and 2.5 μM
Incubation Time: 24 h
Result: Reduced the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: LN-18 cells
Concentration: 0.625 and 1.25 μM
Incubation Time: 24 h
Result: Induced arrest in S phase in a concentration-dependent manner, and exhibited accumulation of 63.38% ± 4.42 at 1.25 μM.
分子量

367.40

Formula

C21H21NO5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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