1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  2. Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis
  3. Fludarabine triphosphate

Fludarabine triphosphate  (Synonyms: F-ara-ATP)

目录号: HY-136650
产品使用指南

Fludarabine triphosphate (F-ara-ATP) 是 Fludarabine (HY-B0069) 的活性代谢物,是一种有效的、非竞争性的、特异性的DNA引发酶 (DNA primase) 抑制剂,其 IC50 为 2.3 μM,Ki 为 6.1 μM。Fludarabine triphosphate 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate 可抑制核糖核苷酸还原酶和DNA聚合酶,最终导致细胞凋亡 (apoptosis)。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Fludarabine triphosphate trisodium 通常具有更好的水溶性和稳定性。

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Fludarabine triphosphate Chemical Structure

Fludarabine triphosphate Chemical Structure

CAS No. : 74832-57-8

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Fludarabine triphosphate 的其他形式现货产品:

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Other Forms of Fludarabine triphosphate:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1][2].

IC50 & Target

IC50: 2.3 ± 0.3 μM (DNA primase); Ki: 6.1 ± 0.3 μM (DNA primase)[1]

体外研究
(In Vitro)

Fludarabine triphosphate is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells[1].
Fludarabine triphosphate (10-50 μM) inhibits the incorporation of ATP into primer RNA and dTTP into DNA to a similar extent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

525.17

Formula

C10H15FN5O13P3

CAS 号
中文名称

三磷酸氟达拉滨

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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