1. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Apoptosis
  2. Glucocorticoid Receptor Apoptosis
  3. Flunisolide hemihydrate

Flunisolide hemihydrate  (Synonyms: 氟尼缩松半水合物)

目录号: HY-B1121A
产品使用指南

Flunisolide hemihydrate 是一种皮质类固醇,是具有口服活性的糖皮质激素受体 ( Glucocorticoid receptor ) 激活剂,具有抗炎活性。Flunisolide hemihydrate 可诱导嗜酸性粒细胞凋亡 (apoptosis),可用于哮喘或鼻炎、炎症的相关研究。

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Flunisolide hemihydrate Chemical Structure

Flunisolide hemihydrate Chemical Structure

CAS No. : 77326-96-6

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation[1][2].

体外研究
(In Vitro)

Flunisolide hemihydrate (0.1-10 μM, 1 h) inhibits lung fibroblast (Isolated from lung) activation[1].
Flunisolide hemihydrate (10 μM, 24 h) reduces MMP-9, TIMP-1, TGF-β and fibronectin release by sputum cells (isolated from mild to moderate asthmatics), and induces sputum eosinophil apoptosis[2].
Flunisolide hemihydrate (0.1-10 µM μM, 24 h) effectively inhibits ICAM-1 expression and GM-CSF and IL-5 release induced by TNF-alpha in BEAS-2B cells[3].
Flunisolide hemihydrate (115 µM, 0-3 h) can be transported in a polarized way in the apical (ap) to basolateral (bl) direction in Calu-3 cells and is demonstrated to be ATP-dependent[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Eosinophil
Concentration: 10 μM
Incubation Time: 24 h
Result: Induced sputum eosinophil apoptosis.
体内研究
(In Vivo)

Flunisolide hemihydrate (Intranasal administration, 0.3-10 µg/mouse, daily, from days 21–27) inhibits lung inflammation, fibrosis, and airway hyper-reactivity, also improves clearance of silica particles from the lungs in silicotic mice[1].
Flunisolide hemihydrate (Intranasal administration, 0.3-10 µg/mouse, daily, from days 21–27) inhibits silica-induced macrophage and myofibroblast accumulation in the lung tissue[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (instilled, intranasally, with crystalline silica, 10 mg/50 µL, particle size 0.5-10 µm)[1]
Dosage: 0.3-10 µg/mouse, daily, from days 21-27
Administration: Intranasal administration
Result: Reduced both granulomatous response, collagen deposition, concerning granuloma formation caused by silica particles.
Reduced the number of F4/80 and α-SMA positive cells.
Clinical Trial
分子量

443.51

Formula

C24H33FO7

CAS 号
中文名称

氟尼缩松半水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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