2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Fluphenazine decanoate dihydrochloride

Fluphenazine decanoate dihydrochloride  (Synonyms: 氟奋乃静癸酸酯（二盐酸化物；二氢氯化物）)

目录号: HY-B1904A
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Fluphenazine decanoate dihydrochloride 是一种多巴胺 D2 受体抑制剂和吩噻嗪类精神安定剂 (neuroleptic)。Fluphenazine decanoate dihydrochloride可用于精神分裂症的研究。

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Fluphenazine decanoate dihydrochloride Chemical Structure

Fluphenazine decanoate dihydrochloride Chemical Structure

CAS No. : 2376-65-0

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Fluphenazine decanoate dihydrochloride 相关抗体

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生物活性

Fluphenazine decanoate dihydrochloride is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research[1][2][3].

IC50 & Target

D2 Receptor

 

体外研究
(In Vitro)

Fluphenazine decanoate dihydrochloride shows activity against T. gondii in human fibroblast cell cultures with an IC50 value of 1.7 mM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fluphenazine decanoate dihydrochloride 相关抗体:
体内研究
(In Vivo)

Fluphenazine decanoate dihydrochloride (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment[2].
Fluphenazine decanoate dihydrochloride (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia[3].
Fluphenazine decanoate dihydrochloride (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cebus apella monkey[2]
Dosage: 0.22 mg/kg and followed by 0.33 mg/kg
Administration: Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks
Result: Decreased the aggressiveness composite behavioral variables (CBV).
Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH.
Animal Model: Male Sprague-Dawley rats (250 g)[3]
Dosage: 25 mg/kg
Administration: Intramuscular injection into the hind limb; 24 weeks
Result: Resulted in spontaneous vacuous chewing mouth movements and jaw tremor.
Animal Model: Adult male rats[4]
Dosage: 1, 2, 3 mg/kg/d
Administration: Subcutaneous injection between 10:00-12:00 h; 60 days
Result: Increased serum prolactin level and suppressed serum LH and FSH levels at day 60.
Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation.
Clinical Trial
分子量

664.69

Formula

C32H46Cl2F3N3O2S
CAS 号
中文名称

氟奋乃静癸酸酯（二盐酸化物；二氢氯化物）
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fluphenazine decanoate dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluphenazine decanoate2376-65-0氟奋乃静癸酸酯（二盐酸化物二氢氯化物）Dopamine Receptorlong-actingphenothiazineneurolepticschizophreniadopamine-D2reproductiveT. gondiihypothalamic tyrosine hydroxylase levelshuman tardive dyskinesiagonadotropin suppressionantifertilityhyperprolactinemiamouth movementsvacuous chewing mouth movementjaw tremorserum prolactinInhibitorinhibitorinhibit

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