2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. FR-167356

FR-167356 是一种口服有效的选择性液泡 ATPase 抑制剂，对破骨细胞质膜、巨噬细胞微粒体、肾刷状缘膜和肝溶酶体膜的 IC50 值分别为 170、220、370 和 1200 nM。FR-167356 抑制骨吸收和卵巢切除术引起的骨丢失。

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FR-167356 Chemical Structure

FR-167356 Chemical Structure

CAS No. : 174185-16-1

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规格 价格 是否有货 数量
1 mg ￥3910
1 周
5 mg   询价  
10 mg   询价  

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FR-167356 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss[1].

体内研究
(In Vivo)

FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 抑制肿瘤生长并降低 MMP9 表达[1]。
FR-167356 (200 mg/kg; 口服; 每天, 持续 10 天; 具有 B16-F10 异种移植物的雄性 C57BL/6 小鼠) 与未处理组相比减少骨转移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male C57BL/6 mice with B16-F10 xenografts[1]
Dosage: 200 mg/kg
Administration: Oral administration; daily, for 10 days
Result: Reduced the expression of MMP9 and reduced bone metastasis.
分子量

378.25

Formula

C19H17Cl2NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FR-167356 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR-167356174185-16-1FR167356FR 167356Proton Pumposteoclast plasma membranesmacrophage microsomesrenal brush border membranesliver lysosomal membranesbone resorptionbone lossInhibitorinhibitorinhibit

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目录号：
HY-123370
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