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  3. Ganaplacide

Ganaplacide  (Synonyms: KAF156; GNF156)

目录号: HY-108024
产品使用指南

Ganaplacide (KAF156) 是一种首创的具有口服活性的咪唑哌嗪类抗疟剂 (antimalarial)。Ganaplacide 对多种疟原虫有活性,包括耐药寄生虫。Ganaplacide 对无性和有性血液阶段以及肝脏阶段都有杀虫作用。

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Ganaplacide Chemical Structure

Ganaplacide Chemical Structure

CAS No. : 1261113-96-5

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Ganaplacide 的其他形式现货产品:

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Other Forms of Ganaplacide:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ganaplacide (KAF156) is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite[1][2].

体外研究
(In Vitro)

Ganaplacide (KAF156) 对恶性疟原虫药物敏感和耐药菌株具有杀血裂殖活性,50% 抑制浓度为 6 至 17.4 nM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ganaplacide (KAF156) (1-15 mg/kg; p.o.) is fully protective in a causal prophylactic mouse model of malaria[1]. Ganaplacide (KAF156) 对成熟的恶性疟原虫配子细胞表现出杀灭活性,从而阻止寄生虫传播给按蚊[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (causal prophylactic rodent malaria model)[1]
Dosage: 1-15 mg/kg
Administration: p.o.
Result: A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
Clinical Trial
分子量

411.45

Formula

C22H23F2N5O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Ganaplacide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ganaplacide
目录号:
HY-108024
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