1. Anti-infection
  2. Parasite
  3. Ganaplacide hydrochloride

Ganaplacide hydrochloride (Synonyms: KAF156 hydrochloride; GNF156 hydrochloride)

目录号: HY-108024A
产品使用指南

Ganaplacide (KAF156) hydrochloride 是一种首创的具有口服咪唑哌嗪类抗疟药。Ganaplacide hydrochloride 对多种疟原虫有活性,包括耐药寄生虫。Ganaplacide hydrochloride 对无性和有性血液阶段以及肝脏阶段都有杀虫作用。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Ganaplacide hydrochloride Chemical Structure

Ganaplacide hydrochloride Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
5 mg ¥5800 In-stock
10 mg ¥8800 In-stock
50 mg ¥25500 Get quote
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite[1][2].

In Vitro

Ganaplacide (KAF156) hydrochloride shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM against P. falciparum drug-sensitive and drug-resistant strains[1].

In Vivo

KAF156 displays cidal activity against mature Plasmodium falciparum gametocytes and thus blocks parasite transmission to Anopheles mosquitoes[1].
Ganaplacide (KAF156) hydrochloride (1-15 mg/kg; p.o.) is fully protective in a causal prophylactic mouse model of malaria[1].

Animal Model: Mice (causal prophylactic rodent malaria model)[1]
Dosage: 1-15 mg/kg
Administration: P.o.
Result: A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
Molecular Weight

447.91

Formula

C₂₂H₂₄ClF₂N₅O

SMILES

FC(C=C1)=CC=C1C2=C(N3C(C(C)(N(C(CN)=O)CC3)C)=N2)NC4=CC=C(F)C=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GanaplacideKAF156GNF156KAF 156KAF-156GNF 156GNF-156Parasitefirst-in-classoralprophylacticcausaltransmissiongametocyteInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Ganaplacide hydrochloride
目录号:
HY-108024A
需求量: