2. MAPK/ERK Pathway Stem Cell/Wnt Cell Cycle/DNA Damage Cytoskeleton
  3. ERK PAK
  4. Gardenin A

Gardenin A  (Synonyms: 栀子(黄)素A)

目录号: HY-N8303
产品使用指南

摩尔计算器

Gardenin A 是一种口服有效的、合成的 PMF 类似物，对神经突生长和神经元分化具有神经营养作用。Gardenin A 通过激活 PC12 细胞中的 MAPK/ERK、PKC 和 PKA 信号通路促进神经细胞的发生，但不激活 TrkA、CREB 信号通路。Gardenin A 也有镇静、抗焦虑、抗抑郁和抗惊厥作用。

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Gardenin A Chemical Structure

Gardenin A Chemical Structure

CAS No. : 21187-73-5

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规格 价格 是否有货 数量
1 mg ￥1849
1 周
5 mg ￥4622
1 周
10 mg ￥7395
1 周
50 mg   询价  
100 mg   询价  

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Customer Review

Gardenin A 相关抗体

Top Publications Citing Use of Products

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ERK ERK1 ERK2 ERK5 ERK8

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PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects[1][2].

体外研究
(In Vitro)

Gardenin A (10-20 μM; 48 h) 可诱导 PC12 细胞神经突生长，(10 μM; 24 小时和 48 小时) 还增加神经元分化和突触形成标记蛋白、生长相关蛋白-43 (GAP-43) 和突触素的表达[1]。
Gardenin A (10 μM; 30-120分钟) 显著诱导环 AMP 反应元件结合蛋白(CREB) 的磷酸化和 CRE 介导的转录，这是通过抑制剂 2-萘酚AS-E 磷酸盐 (KG-501) 或使用 CREB siRNA 来抑制的[1]。
Gardenin A (10 μM; 15-120分钟) 增加 ERK 磷酸化水平，提高 PKA 和 PKC 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gardenin A 相关抗体:

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 2, 5, 10, 20 μM
Incubation Time: 48 hours
Result: showed cell growth supporting effect at higher concentrations (10-20 µM) and did not exert detectable 237 cytotoxicity on PC12 cells after 48 h incubation in low serum medium.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 10 μM
Incubation Time: 0, 15, 30, 60, and 120 min
Result: Significantly increased the phosphorylation of ERK1/2 (Thr202/Tyr204) at 15 min, subsequently reduced after 30 min.
Increased PKC and PKA activity peaked at 15 min. Increased CREB phosphorylation.
体内研究
(In Vivo)

Gardenin A (0.1-25 mg/kg; 口服; 单剂量) 具有神经药理作用，包括镇静、抗焦虑、抗抑郁和抗惊厥作用的小鼠[2]。
栀子苷A (1-10 mg/kg; 口服; 单次剂量) 不影响小鼠的运动协调和延迟惊厥的发生[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c mice (24-32 g)[2]
Dosage: 1 mg/kg, 10 mg/kg, 25 mg/kg
Administration: Oral gavage; single dose
Result: Showed sedative effects at a dose of 25 mg/kg, which increased the duration of sleep but did not alter sleep onset.
分子量

418.39

Formula

C21H22O9
CAS 号
中文名称

栀子(黄)素A
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gardenin A 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gardenin A21187-73-5栀子(黄)素AERKPAKExtracellular signal regulated kinasesp21 activated kinasesInhibitorinhibitorinhibit

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