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  5. Gardneramine

Gardneramine 是一种口服有效的生物碱,具有类似罂粟碱的作用。Gardneramine 具有外周血管舒张作用、对心肌的直接抑制作用和中枢抑制作用。Gardneramine 在家兔、狗和豚鼠模型中,分别表现出降压、血管扩张、和心房抑制作用。Gardneramine 还抑制胃和肠等平滑肌器官的运动。

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Gardneramine Chemical Structure

Gardneramine Chemical Structure

CAS No. : 34274-91-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines[1].

体外研究
(In Vitro)

Gardneramine (80 μg/mL; 0-20 min) 对豚鼠的心房产生抑制作用[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Gardneramine (4 mg/kg; 静脉注射; 单剂量) 在兔子中导致血压下降 (36.6%)[1]
Gardneramine (0.2 mg/kg, 0.4 mg/kg; 动脉注射; 单剂量) 在狗的后肢中增加血液流速,产生血管扩张作用[1]
Gardneramine (20 mg/kg, 40 mg/kg, and 80 mg/kg; 腹腔注射; 单剂量) 在小鼠中抑制胃和肠等平滑肌器官的运动[1]
Gardneramine (20 mg/kg; 口服; 单剂量) 处理小鼠后摘除小肠,显示出松弛作用,轻微抑制应激性离子产生[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

412.48

Formula

C23H28N2O5

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-N3931
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