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  4. Gd-NMC-3

Gd-NMC-3 是一种近红外荧光/磁共振 (NIRF/MR) 双峰成像探针。Gd-NMC-3 在肿瘤成像中具有高分辨率和灵敏度，并且生物相容性好。

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Gd-NMC-3 Chemical Structure

Gd-NMC-3 Chemical Structure

CAS No. : 2678579-76-3

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Gd-NMC-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential[1].

体外研究
(In Vitro)

Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region[1].
Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites[1].
Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues[1].
Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors[1].
Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gd-NMC-3 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 and LM3: human hepatocarcinoma cell line; L02: human hepatocyte cell line
Concentration: 6.25-100 μM
Incubation Time: 48 hours
Result: Resulted more than 90% cell viability maintained after 48 h.
体内研究
(In Vivo)

Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 subcutaneous xenograft mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection; 1.5 h later dissected tumors
Result: Accumulated in the tumor after injection and produced stronger fluorescence intensity in tumor tissues.
Remained fluorescence signal longer than 1.5 h, and provided high-resolution images of the tumor tissues with a SNR of 4.32.
Animal Model: LM3 orthotopic mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection
Result: Decreased gradually the fluorescence intensity in LM3 orthotopic liver tumors after administration, whereas tumor-to-skin fluorescence ratios increased due to high accumulation and low clearance in tumor tissues.
分子量

1968.46

Formula

C77H116Gd2N14O22S2
CAS 号
Emission (Em)

800
Excitation (Ex)

780
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gd-NMC-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gd-NMC-32678579-76-3Fluorescent Dyenear-infraredmagnetic resonanceNIRF/MR imagingnear-infrared fluorescence/magnetic resonancebimodal imaging moleculelow cytotoxicitybiocompatibilityrelaxation propertyfluorescence accumulationmultimodality imagingcovalently coupledDCDSTCYGd-DOTAbutane diamineInhibitorinhibitorinhibit

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