2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Gemlapodect

Gemlapodect  (Synonyms: RO554965)

目录号: HY-152838
产品使用指南

摩尔计算器

Gemlapodect (RO554965) 是一种磷酸二酯酶 10A (PDE10A) 抑制剂。Gemlapodect 可用于研究精神分裂症。

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Gemlapodect Chemical Structure

Gemlapodect Chemical Structure

CAS No. : 1380329-87-2

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Gemlapodect 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia[1].

IC50 & Target[1]

PDE10A

 

体内研究
(In Vivo)

Gemlapodect (5-15 mg；口服；一天一次持续 6 周) 显著改善儿童期发作性流利性障碍 (COFD) 患者的工作和生活社会功能，显示出生物安全性[2]。
Gemlapodect (10 mg/kg；口服；单剂量) 在 9 周龄的 SD 大鼠中不改变葡萄糖耐受性。[2]。
Gemlapodect (0.3 mg/kg；口服；一天一次持续 8 天) 在 10 周龄的 SD 大鼠中诱导葡萄糖耐受性轻微改善，空腹血糖无变化，空腹胰岛素降低[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male patients with COFD (18-50 years old)[2].
Dosage: 5-15 mg.
Administration: Oral gavage; once daily for 6 weeks.
Result: Improved the Stuttering, work, social life, family life and home responsibilities of COFD patients and showed biosafety.
Animal Model: 9 weeks or 10 weeks male SD rats[2].
Dosage: 0.3 mg/kg or 10 mg/kg.
Administration: Oral gavage; once daily for 1 or 8 days.
Result: Showed insignificantly change of glucose tolerance in healthy rats.
分子量

431.45

Formula

C22H21N7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gemlapodect 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemlapodect1380329-87-2RO554965RO 554965RO-554965Phosphodiesterase (PDE)SchizophreniaInhibitorinhibitorinhibit

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