2. Gene
  3. Cdk5r1 - cyclin-dependent kinase 5 regulatory subunit 1 Gene

Cdk5r1 - cyclin-dependent kinase 5 regulatory subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: p35; Cdk5r

基因 ID: 116671 | 基因类型: protein coding

关于 Cdk5r1

功能概要

Enables several functions, including Cadherin binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and Ephrin Receptor binding activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; nervous system development; and regulation of synaptic vesicle cycle. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Part of protein kinase 5 complex. Is active in presynapse. Biomarker of hypothyroidism and trigeminal neuralgia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5r1 基因产物(1)

mRNA Protein Name
NM_053891.2 NP_446343.1 cyclin-dependent kinase 5 activator 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IDA
IDA: 通过直接分析推断
10753743 RGD
enables calcium ion binding IDA
IDA: 通过直接分析推断
12223541 RGD
enables cyclin-dependent protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
8662984 RGD
enables cyclin-dependent protein serine/threonine kinase activator activity IGI
IGI: 通过遗传相互作用推断
17517623 RGD
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
17143272 RGD
enables kinase activity IDA
IDA: 通过直接分析推断
8846918 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8846918 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
25665755 RGD
enables protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
8662984 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: 通过直接分析推断
11276227 RGD
involved in embryo development ending in birth or egg hatching IDA
IDA: 通过直接分析推断
11276227 RGD
involved in ionotropic glutamate receptor signaling pathway IDA
IDA: 通过直接分析推断
12223541 RGD
involved in neuron differentiation IDA
IDA: 通过直接分析推断
8846918 RGD
involved in neuron projection development IMP
IMP: 通过突变表型推断
8846918 RGD
involved in positive regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
16192386 RGD
involved in regulation of synaptic vesicle cycle IDA
IDA: 通过直接分析推断
24254883 RGD
involved in regulation of synaptic vesicle cycle IEP
IEP: 通过表达模式推断
24254883 RGD
involved in regulation of synaptic vesicle cycle IMP
IMP: 通过突变表型推断
24254883 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
8846918 RGD
located in contractile muscle fiber IDA
IDA: 通过直接分析推断
11276227 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
11276227 RGD
located in dendrite IDA
IDA: 通过直接分析推断
8846918 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
12223541 RGD
located in growth cone IDA
IDA: 通过直接分析推断
8846918 RGD
located in membrane IDA
IDA: 通过直接分析推断
11276227 RGD
located in neuromuscular junction IDA
IDA: 通过直接分析推断
11276227 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
8846918 RGD
located in nucleus IDA
IDA: 通过直接分析推断
16192386 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
17143272 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
24254883 RGD
part of protein kinase 5 complex IDA
IDA: 通过直接分析推断
8662984 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclin-dependent kinase 5 activator 1

CDK5 activator 1

TPKII regulatory subunit

p23

tau protein kinase II 23 kDa subunit

Cdk5r1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Cdk5r1 P61810 Cdk5 Rattus norvegicus Q03114
Anti Bait CoIP
17036052
种属内
Cdk5r1 P61810 Cdk5 Rattus norvegicus Q03114
Anti Bait CoIP
17341134
种属内
Cdk5r1 P61810 Fzr1 Rattus norvegicus B1WCA1
Protein Kinase Assay
18818692
种属内
Cdk5r1 P61810 Fzr1 Rattus norvegicus B1WCA1
Anti Bait CoIP
18818692
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02387 CDK5R1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20536 Cdk5r1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27045 Cdk5r1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk5r1 NCBI NCBI:8851
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