2. Gene
  3. Cdk5 - cyclin-dependent kinase 5 Gene

Cdk5 - cyclin-dependent kinase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 5

种属: Rattus norvegicus

基因 ID: 140908 | 基因类型: protein coding

关于 Cdk5

Primary_assembly 4: 10,754,687-10,760,112 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 170 orthologues, 24 paralogues and is associated with 16 phenotypes. Biased expression in Brain (RPKM 242.9), Adrenal (RPKM 12.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括肝配蛋白受体结合活性；蛋白激酶活性；电压门控钙通道活动参与突触前细胞溶质钙水平的正调节。参与多个过程，包括对淀粉样蛋白-β 的细胞反应；凋亡过程的正调控；和蛋白质磷酸化。作用于蛋白质磷酸化的上游或内部。位于多个细胞成分中，包括生长锥；神经细胞体；和突触后密度。蛋白激酶 5 复合体的一部分。活跃于多种细胞成分，包括 Schaffer 侧支 - CA1 突触；谷氨酸能突触；和神经肌肉接头。与微管共定位。用于研究脑缺血；精神抑郁症；和三叉神经痛。阿尔茨海默病的生物标志物；短暂性脑缺血；和血管性痴呆。该基因的人类直系同源物与阿尔茨海默氏病和伴有小脑发育不全的无脑畸形 7 有关。与人 CDK5（细胞周期蛋白依赖性激酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Ephrin Receptor binding activity; protein kinase activity; and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Colocalizes with microtubule. Used to study brain ischemia; mental depression; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5 基因产物(1)

mRNA Protein Name
NM_080885.2 NP_543161.1 cyclin-dependent kinase 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11675505 RGD
enables cytoskeletal protein binding IPI
IPI: 通过物理相互作用推断
9313898 RGD
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
17143272 RGD
enables histone kinase activity IDA
IDA: 通过直接分析推断
16407116 RGD
enables kinase activity IDA
IDA: 通过直接分析推断
8846918 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8846918 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
12084709 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
19700222 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
8662984 RGD
enables tau-protein kinase activity IDA
IDA: 通过直接分析推断
15994305 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
19151707 RGD
involved in cellular response to amyloid-beta IDA
IDA: 通过直接分析推断
26224839 RGD
involved in cortical actin cytoskeleton organization IMP
IMP: 通过突变表型推断
15331630 RGD
involved in exocytosis IMP
IMP: 通过突变表型推断
15331630 RGD
involved in mitochondrion organization IMP
IMP: 通过突变表型推断
28153522 RGD
involved in neuron apoptotic process IMP
IMP: 通过突变表型推断
15592431 RGD
involved in neuron differentiation IDA
IDA: 通过直接分析推断
8846918 RGD
involved in neuron projection development IMP
IMP: 通过突变表型推断
8846918 RGD
involved in neuron projection morphogenesis IMP
IMP: 通过突变表型推断
12535933 RGD
involved in nucleocytoplasmic transport IMP
IMP: 通过突变表型推断
16887799 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
12691662 RGD
involved in positive regulation of glial cell apoptotic process IMP
IMP: 通过突变表型推断
28153522 RGD
involved in positive regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
16192386 RGD
involved in positive regulation of presynaptic cytosolic calcium concentration IMP
IMP: 通过突变表型推断
23699505 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
28153522 RGD
involved in positive regulation of voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
23699505 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
15992363 RGD
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
17202132 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
8662984 RGD
involved in regulated exocytosis IMP
IMP: 通过突变表型推断
15331630 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
23699505 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
23699505 RGD
involved in regulation of synapse pruning EXP
EXP: 通过实验结果推断
17143272 RGD
involved in regulation of synapse pruning IDA
IDA: 通过直接分析推断
17143272 RGD
involved in regulation of synapse pruning IMP
IMP: 通过突变表型推断
17143272 RGD
involved in regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
11675505 RGD
involved in skeletal muscle tissue development IEP
IEP: 通过表达模式推断
15208659 RGD
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
12855954 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse EXP
EXP: 通过实验结果推断
17143272 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
17143272 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
17143272 RGD
located in axon IDA
IDA: 通过直接分析推断
8846918 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
10683146 RGD
located in dendrite IDA
IDA: 通过直接分析推断
8846918 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
17143272 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17143272 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17143272 RGD
located in growth cone IDA
IDA: 通过直接分析推断
8846918 RGD
located in membrane IDA
IDA: 通过直接分析推断
10683146 RGD
located in microtubule IDA
IDA: 通过直接分析推断
17491008 RGD
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
11276227 RGD
located in neuromuscular junction IDA
IDA: 通过直接分析推断
11276227 RGD
located in neuron projection IDA
IDA: 通过直接分析推断
10683146 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
8846918 RGD
located in nucleus IDA
IDA: 通过直接分析推断
16192386 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
11276227 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
17143272 RGD
located in presynapse IMP
IMP: 通过突变表型推断
23699505 RGD
part of protein kinase 5 complex IDA
IDA: 通过直接分析推断
8662984 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cdk5 蛋白结构

STKc_CDK5

STKc_CDK5: cd07839 (2 - 285)

  • 0
  • 100
  • 200
  • 292 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 5

TPKII catalytic subunit

cell division protein kinase 5

cyclin-dependent-like kinase 5

serine/threonine-protein kinase PSSALRE

tau protein kinase II catalytic subunit

Cdk5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Cdk5 Q03114 Cdk5r1 Rattus norvegicus P61810
Anti Bait CoIP
17341134
种属间
Cdk5 Q03114 NTRK2 Homo sapiens Q16620
Protein Kinase Assay
17341134
种属间
Cdk5 Q03114 NTRK2 Homo sapiens Q16620
Anti Tag CoIP
17341134
种属内
Cdk5 Q03114 Ntrk2 Rattus norvegicus Q63604
Protein Kinase Assay
17341134
种属内
Cdk5 Q03114 Ntrk2 Rattus norvegicus Q63604
Anti Bait CoIP
17341134
种属内
Cdk5 Q03114 Ntrk3 Rattus norvegicus Q03351
Protein Kinase Assay
17341134
种属内
Cdk5 Q03114 Ntrk3 Rattus norvegicus Q03351
Anti Bait CoIP
17341134
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16297A Abemaciclib Inhibitor 99.97% 是
HY-10492 Dinaciclib Inhibitor 99.80% 是
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
Clinical Phase
生物活性分子 (20)
目录号 产品名 作用方式
纯度 Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-30237 (R)-Roscovitine Inhibitor 99.53% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-137478A KB-0742 dihydrochloride Inhibitor 99.24% Phase 2
HY-X0009 Tambiciclib Inhibitor 99.21% Phase 2
HY-137478 KB-0742 Inhibitor 99.38% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-103712 Samuraciclib Inhibitor / Phase 2
HY-X0009A Tambiciclib dimaleate Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.87% Phase 1
HY-50940A AT7519 TFA Inhibitor 96.62% Phase 1
Pre-clinical Phase
生物活性分子 (65)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12302 Kenpaullone Inhibitor 98.20% 否
HY-18340 (R)​-​CR8 Inhibitor 99.61% 否
HY-15154 NG 52 Inhibitor 99.88% 否
HY-11009 CGP60474 Inhibitor 98.90% 否
HY-18299A Purvalanol A Inhibitor 98.61% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% 否
HY-108359 Alsterpaullone Inhibitor 99.85% 否
HY-12280 THZ2 Inhibitor 99.03% 否
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% 否
HY-144117 GFB-12811 Inhibitor 98.04% 否
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.62% 否
HY-X0150 JSH-150 Inhibitor 98.66% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.93% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-18299 Purvalanol B Inhibitor 97.0% 否
HY-103221 MeBIO Inhibitor 98.0% 否
HY-145694 CDK5-IN-3 Inhibitor 99.49% 否
HY-112358 GW8510 Inhibitor 99.04% 否
HY-W011428 Olomoucine Inhibitor 99.87% 否
HY-13461 PHA-767491 Inhibitor 99.85% 否
HY-107419 NU6140 Inhibitor 99.07% 否
HY-154851 GSK-3 inhibitor 3 Inhibitor 98.72% 否
HY-117025A Manzamine A hydrochloride Inhibitor 99.66% 否
HY-15241 NVP-LCQ195 Inhibitor 98.81% 否
HY-155218 TMX-2172 Degrader 99.38% 否
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 99.50% 否
HY-136726 CGP-82996 Inhibitor 98.12% 否
HY-14372 BS-194 Inhibitor 99.36% 否
HY-P10440 Cdk5i peptide Inhibitor 99.83% 否
HY-112403 (S)-Roscovitine Inhibitor 99.15% 否
HY-121035 7BIO Inhibitor 99.20% 否
HY-123045 PNU-292137 Inhibitor 99.95% 否
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% 否
HY-103381 NSC693868 Inhibitor 99.0% 否
HY-151069 TMX-2039 Inhibitor 99.42% 否
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% 否
HY-103383 (R)-DRF053 dihydrochloride Inhibitor 99.30% 否
HY-119715 AG-012986 Inhibitor 99.78% 否
HY-154852 GSK-3 inhibitor 4 Inhibitor 98.77% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-139725 CDK5-IN-1 Inhibitor 98.47% 否
HY-117025 Manzamine A Inhibitor 98.2% 否
HY-114903 (E/Z)-BIO-acetoxime Inhibitor 99.0% 否
HY-151407 CDK1-IN-3 Inhibitor / 否
HY-110368 BS-181 dihydrochloride Inhibitor / 否
HY-151409 CDK1-IN-5 Inhibitor / 否
HY-178142 Multi-kinase-IN-7 Inhibitor / 否
HY-173347 BLINK11 Inhibitor / 否
HY-150641 CDK-IN-9 Inhibitor / 否
HY-137478B KB-0742 hydrochloride Inhibitor / 否
HY-164906 TMX-2138 Degrader / 否
HY-161463 CDK2-IN-28 Inhibitor / 否
HY-173348 BLINK15 Inhibitor / 否
HY-145693 CDK5-IN-2 Inhibitor / 否
HY-161595 CDK5-IN-4 Inhibitor / 否
HY-163856 CDK7-IN-30 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-112363 Aloisine A Inhibitor / 否
HY-151408 CDK1-IN-4 Inhibitor / 否
HY-112336 Aloisine RP106 Inhibitor / 否
HY-151071 TMX-3013 Inhibitor / 否
HY-111932 Indirubin-5-sulfonate Inhibitor / 否
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk5 NCBI NCBI:1020
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