Fgfr4 - fibroblast growth factor receptor 4 Gene

中文名称：成纤维细胞生长因子受体 4

种属: Mus musculus

同用名: Fgfr-4

关于 Fgfr4

功能概要

预测该基因编码的蛋白编码的蛋白可启动成纤维细胞生长因子结合活性；成纤维细胞生长因子激活受体活性；和肝素结合活性。参与多个过程，包括胆固醇稳态；磷酸根离子稳态；胆汁酸生物合成过程的调控。作用于多个过程的上游或内部，包括肺泡继发性隔膜发育；成纤维细胞生长因子产生的负调节；及甲状旁腺激素分泌的正调节作用。预计位于多个细胞成分中，包括高尔基体；内质网；和运输囊泡。预计是受体复合体的一部分。预计是质膜的组成部分。预测与细胞-细胞连接共定位。以多种结构表达，包括消化系统；脑;泌尿生殖系统；肌肉骨骼系统;和感觉器官。该基因的人类直系同源物与癌症有关（多个）；肝硬化;前列腺癌;和胃癌。与人 FGFR4（成纤维细胞生长因子受体 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Fibroblast Growth Factor binding activity; fibroblast growth factor-activated receptor activity; and heparin binding activity. Involved in several processes, including Cholesterol homeostasis; phosphate ion homeostasis; and regulation of bile acid biosynthetic process. Acts upstream of or within several processes, including alveolar secondary septum development; negative regulation of Fibroblast Growth Factor production; and positive regulation of parathyroid hormone secretion. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and transport vesicle. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Predicted to colocalize with cell-cell junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in carcinoma (multiple); liver cirrhosis; prostate cancer; and stomach Cancer. Orthologous to human FGFR4 (Fibroblast Growth Factor receptor 4). [provided by Alliance of Genome Resources, Apr 2022]