FGFR-4 蛋白, Mouse (HEK293, His-Fc)

FGFR-4 protein is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factor and controls proliferation, differentiation, migration, lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism, and phosphate and other cellular processes homeostasis. It significantly downregulates CYP7A1 in response to FGF19. FGFR-4 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived FGFR-4 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of FGFR-4 Protein, Mouse (HEK293, His-Fc) is 366 a.a., with molecular weight of 100-110 kDa.

FGFR-4 蛋白是一种酪氨酸蛋白激酶，作为成纤维细胞生长因子的细胞表面受体，调节细胞增殖、分化、迁移、脂质代谢、胆汁酸生物合成、葡萄糖摄取、维生素 D 代谢和磷酸盐稳态。它对于 CYP7A1 表达的正常下调至关重要，CYP7A1 是参与胆汁酸合成的酶，响应 FGF19。配体结合后，FGFR-4 磷酸化 PLCG1 和 FRS2，导致多个信号级联的激活。PLCG1 的激活导致二酰基甘油和肌醇 1,4,5-三磷酸的产生。FRS2 的磷酸化会招募 GRB2、GAB1、PIK3R1 和 SOS1，从而激活 RAS、MAPK1/ERK2、MAPK3/ERK1 和 AKT1 信号通路。FGFR-4 还促进基质蛋白酶 MMP14 的 SRC 依赖性磷酸化和溶酶体降解，其中 MMP14 有助于 FGFR-4 的内化和降解。此外，FGFR-4 在出生后肺部发育中发挥作用，并可能参与骨骼肌细胞谱系发育。

Mouse

HEK293

C-hFc;C-His

Q03142 (M1-D366)

14186  [NCBI]

MWLLLALLSIFQGTPALSLEASEEMEQEPCLAPILEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLLMDDSLTSISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTD

100-110 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.