1. Protein Tyrosine Kinase/RTK
  2. FGFR
  3. FGFR4-IN-1

FGFR4-IN-1 

目录号: HY-100631 纯度: 99.89%
产品使用指南

FGFR4-IN-1 是有效的 FGFR4 抑制剂,IC50 值为 0.7 nM。

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FGFR4-IN-1 Chemical Structure

FGFR4-IN-1 Chemical Structure

CAS No. : 1708971-72-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1300
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5 mg ¥1200
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10 mg ¥2300
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50 mg ¥7000
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100 mg ¥9900
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查看 FGFR 亚型特异性产品:

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.

IC50 & Target

FGFR4

0.7 nM (IC50)

体外研究
(In Vitro)

FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC50 of 7.8 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

493.52

Formula

C24H27N7O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 6.4 mg/mL (12.97 mM; Need warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0263 mL 10.1313 mL 20.2626 mL
5 mM 0.4053 mL 2.0263 mL 4.0525 mL
10 mM 0.2026 mL 1.0131 mL 2.0263 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
Cell Assay
[1]

Methylene blue staining proliferation assay (MBS): The effect of compounds on cell proliferation is assessed using HuH-7 hepatocellular carcinoma cells are cultured in the vendor-recommended medium. Specifically, 5000 cells/well are seeded in 96-well tissue culture plates in a total media volume of 100 μL/well and increasing compound dilutions or DMSO are added 24 hours thereafter in triplicates. 72 hours after compound addition, cells are fixed by adding 25 and incubated for 10 minutes at room temperature. Cells are washed three times with H2O. Cells are washed 3 times with H2O, 200 mL/well and then lysed by adding 200 mL/well of 3% HCl for 30 minutes at room temperature with shaking. Optical density is measured at A650 nm. The concentration of compound providing 50% of proliferation inhibition with respect to DMSO-treated cells is determined (IC50) using XLFit software.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
FGFR4-IN-1
目录号:
HY-100631
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