2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  3. FGFR p38 MAPK Akt ERK Apoptosis
  4. FGFR-IN-23

FGFR-IN-23 (Compound 9p) 是一种共价泛 FGFR 抑制剂，对 FGFR1、FGFR2、FGFR3 和 FGFR4 的 IC50 分别为 14 nM、4.2 nM、5 nM 和 220 nM。FGFR-IN-23 对门控基因突变体 (如 FGFR1V561M 和 FGFR3V555M) 也具有强效抑制活性。FGFR-IN-23 抑制 FGFR 介导的信号传导激活并诱导细胞凋亡 (apoptosis)。FGFR-IN-23 在 RT112 异种移植小鼠模型中表现出显著的抗肿瘤功效。FGFR-IN-23 可用于癌症及其耐药性研究。

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FGFR-IN-23

FGFR-IN-23 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

FGFR-IN-23 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGFR-IN-23 (Compound 9p) is a covalent pan FGFR inhibitor with IC50s of 14, 4.2, 5 and 220 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-23 also has potent inhibitory activity against gatekeeper mutants, such as FGFR1V561M and FGFR3V555M. FGFR-IN-23 suppresses the activation of FGFR-mediated signaling and induces apoptosis. FGFR-IN-23 shows significant antitumor efficacy in RT112 xenograft mouse models. FGFR-IN-23 can be used for cancers and its drug resistance research[1].

IC50 & Target[1]

FGFR1

14 nM (IC50)

FGFR2

4.2 nM (IC50)

FGFR3

5 nM (IC50)

FGFR4

220 nM (IC50)

分子量

496.56

Formula

C27H28N8O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FGFR-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-23FGFRp38 MAPKAktERKApoptosisFibroblast growth factor receptorPKBProtein kinase BExtracellular signal regulated kinasesAntitumorRT112 xenograft mouse modelsBa/F3 FGFR2V564F cellsKATO III cellsCancersInhibitorinhibitorinhibit

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产品名称：
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目录号：
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