1. Gene
  2. Pcna - proliferating cell nuclear antigen Gene

Pcna - proliferating cell nuclear antigen Gene

种属: Mus musculus

基因 ID: 18538 | 基因类型: protein coding

关于 Pcna

功能概要

Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in nuclear lamina and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; brain; forelimb; heart; and sensory organ. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]

Pcna 基因产物(1)

mRNA Protein Name
NM_011045.2 NP_035175.1 proliferating cell nuclear antigen
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
24115439 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10888872 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
19023449 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within base-excision repair, gap-filling IDA
IDA: 通过直接分析推断
15177179 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
24726645 MGI
involved in mitotic telomere maintenance via semi-conservative replication IGI
IGI: 通过遗传相互作用推断
24115439 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19023449 MGI
involved in replication fork processing IGI
IGI: 通过遗传相互作用推断
24115439 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
12970760 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
16489008 MGI
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
12638230 MGI
located in nuclear lamina IDA
IDA: 通过直接分析推断
10888872 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10079221 MGI
located in replication fork IDA
IDA: 通过直接分析推断
11934988 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

proliferating cell nuclear antigen

cyclin

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pcna NCBI NCBI:5111