2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 255

Anticancer agent 255是一种单碳酰化姜黄素-1,2,3-噁唑结合物，具有显著的抗癌活性。Anticancer agent 255在前列腺癌细胞PC-3和DU-145中的IC50值分别为8.8μM和9.5μM。Anticancer agent 255对乳腺癌细胞MCF-7、MDA-MB-231和4T1的IC50值为6μM、10μM和6.4μM，显示出良好的抗癌效果。Anticancer agent 255能够诱导癌细胞的线粒体介导的凋亡，并且阻止细胞周期进程。Anticancer agent 255下调了细胞增殖标记物PCNA，并抑制了细胞生存蛋白的活化。Anticancer agent 255上调了促凋亡蛋白Bax，同时下调了抗凋亡蛋白Bcl-2。

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Anticancer agent 255

Anticancer agent 255 Chemical Structure

CAS No. : 1983924-20-4

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Anticancer agent 255 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 255 is a monocarbonylated curcumin-1,2,3-oxazole conjugate with significant anticancer activity. The IC50 values of Anticancer agent 255 in prostate cancer cells PC-3 and DU-145 are 8.8μM and 9.5μM respectively. The IC50 values of Anticancer agent 255 against breast cancer cells MCF-7, MDA-MB-231 and 4T1 are 6μM, 10μM and 6.4μM, showing good anti-cancer activity Effect. Anticancer agent 255 can induce mitochondria-mediated apoptosis in cancer cells and prevent cell cycle progression. Anticancer agent 255 down-regulated the cell proliferation marker PCNA and inhibited the activation of cell survival proteins. Anticancer agent 255 up-regulated the pro-apoptotic protein Bax and down-regulated the anti-apoptotic protein Bcl-2[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
18 μM
Compound: 17
Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
DU-145 IC50
9.5 μM
Compound: 17
Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
HEK293 IC50
> 100 μM
Compound: 17
Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
MCF7 IC50
28.7 μM
Compound: 17
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
MDA-MB-231 IC50
10 μM
Compound: 17
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
PC-3 IC50
8.8 μM
Compound: 17
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
分子量

492.59

Formula

C31H29FN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 255 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2551983924-20-4Anticancer agent255Anticancer agent-255ApoptosisInhibitorinhibitorinhibit

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