2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Antitumor agent-163

Antitumor agent-163 (Compound 3) 是针对碳酸酐酶IX (Carbonic Anhydrase IX, CAIX) 的分子靶向光动力疗法 (Molecular-Targeted Photodynamic Therapy, MT-PDT) 中使用的一种光敏剂。Antitumor agent-163 在 540 nm 波长的光照下通过单线态氧灭活 CAIX 蛋白，而不会影响内部标准蛋白，如 α-微管蛋白 (α-tubulin)、β-肌动蛋白 (β-actin) 和增殖细胞核抗原 (PCNA)。Antitumor agent-163 诱导细胞膜损伤，抑制细胞活力 (A549 和 U87MG 的 IC50 分别为 0.2 和 0.05 μM)。Antitumor agent-163 在小鼠模型中表现出抗肿瘤活性。

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Antitumor agent-163

Antitumor agent-163 Chemical Structure

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Antitumor agent-163 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA IX CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.2 μM
Compound: 3
Photodynamic antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
Photodynamic antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
[PMID: 38810709]
U-87MG ATCC IC50
0.05 μM
Compound: 3
Photodynamic antitumor activity against human U87 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
Photodynamic antitumor activity against human U87 cells assessed as inhibition of cell growth incubated for 60 mins followed by compound washout and light irradiation measured after 72 hrs by MTT assay
[PMID: 38810709]
分子量

825.26

Formula

C27H32BF2I2N5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-163 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-163Antitumor agent163Antitumor agent 163Carbonic AnhydraseCarbonate dehydrataseA549U87MGphotosensitizerInhibitorinhibitorinhibit

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