1. Cell Cycle/DNA Damage
    Apoptosis
  2. DNA/RNA Synthesis
    Apoptosis
  3. AOH1160

AOH1160 

目录号: HY-120836
产品使用指南

AOH1160 是一种有效的可口服的小分子增殖细胞核抗原 (PCNA) 抑制剂,干扰 DNA 复制,阻断同源重组介导的 DNA 修复,导致细胞周期停滞并诱导细胞凋亡。 AOH1160 选择性杀死多种类型的癌细胞 (平均 GI50=330 nM),不会对广泛的非恶性细胞造成显着毒性。

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AOH1160 Chemical Structure

AOH1160 Chemical Structure

CAS No. : 2089314-57-6

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Description

AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis. AOH1160 selectively kills many types of cancer cells (mean GI50=330 nM) without causing significant toxicity to a broad range of nonmalignant cells[1].

IC50 & Target

IC50: PCNA[1]

Molecular Weight

396.44

Formula

C₂₅H₂₀N₂O₃

CAS No.

2089314-57-6

SMILES

O=C(C1=C2C=CC=CC2=CC=C1)NCC(NC3=CC=CC=C3OC4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
AOH1160
目录号:
HY-120836
需求量:

AOH1160

Cat. No.: HY-120836