Wnt3a - wingless-type MMTV integration site family, member 3A Gene

种属: Mus musculus

同用名: vt; Wnt-3a

基因 ID: 22416 | 基因类型: protein coding

关于 Wnt3a

功能概要

Enables protein domain specific binding activity; signaling receptor binding activity; and transcription coactivator activity. Involved in several processes, including COP9 signalosome assembly; calcium ion transmembrane transport via low voltage-gated calcium channel; and nervous system development. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; genitourinary system; and sensory organ. Orthologous to human WNT3A (Wnt family member 3A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt3a 基因产物(1)

mRNA	Protein	Name
NM_009522.3	NP_033548.1	protein Wnt-3a precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables frizzled binding	IDA IDA: 通过直接分析推断	19910923	MGI
enables frizzled binding	IPI IPI: 通过物理相互作用推断	18606138	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	31036956	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	10866835	MGI
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	15454084	MGI
enables receptor ligand activity	IDA IDA: 通过直接分析推断	10557084	MGI
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	17994217	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of B cell proliferation	IDA IDA: 通过直接分析推断	10933391	MGI
involved in COP9 signalosome assembly	IDA IDA: 通过直接分析推断	17569865	MGI
involved in Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	16115200	MGI
acts upstream of or within Wnt signaling pathway involved in forebrain neuroblast division	IMP IMP: 通过突变表型推断	10631167	MGI
acts upstream of or within anterior/posterior pattern specification	IDA IDA: 通过直接分析推断	15148409	MGI
acts upstream of or within axis elongation involved in somitogenesis	IGI IGI: 通过遗传相互作用推断	11029008	MGI
acts upstream of or within axon guidance	IDA IDA: 通过直接分析推断	18716223	MGI
acts upstream of or within axonogenesis	IDA IDA: 通过直接分析推断	15454084	MGI
acts upstream of or within axonogenesis	IGI IGI: 通过遗传相互作用推断	15454084	MGI
involved in calcium ion transmembrane transport via low voltage-gated calcium channel	IDA IDA: 通过直接分析推断	20371816	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	31222549	MGI
involved in canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	10557084	MGI
involved in canonical Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	10409711	MGI
involved in canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	19701191	MGI
acts upstream of or within cardiac muscle cell fate commitment	IGI IGI: 通过遗传相互作用推断	21554246	MGI
involved in cell proliferation in forebrain	IDA IDA: 通过直接分析推断	12843296	MGI
involved in cell proliferation in midbrain	IDA IDA: 通过直接分析推断	14557550	MGI
acts upstream of cytokine production	IDA IDA: 通过直接分析推断	23677472	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: 通过突变表型推断	16291790	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: 通过突变表型推断	8299937	MGI
acts upstream of or within extracellular matrix organization	IDA IDA: 通过直接分析推断	17943183	MGI
acts upstream of fat cell differentiation	IDA IDA: 通过直接分析推断	17888405	MGI
acts upstream of fat cell differentiation	IGI IGI: 通过遗传相互作用推断	17888405	MGI
acts upstream of or within heart looping	IMP IMP: 通过突变表型推断	16291790	MGI
acts upstream of or within hemopoiesis	IDA IDA: 通过直接分析推断	12717450	MGI
acts upstream of or within hippocampus development	IMP IMP: 通过突变表型推断	10631167	MGI
acts upstream of or within in utero embryonic development	IMP IMP: 通过突变表型推断	4819561	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: 通过遗传相互作用推断	15961523	MGI
acts upstream of or within mammary gland development	IDA IDA: 通过直接分析推断	15342465	MGI
acts upstream of or within mesoderm development	IMP IMP: 通过突变表型推断	8299937	MGI
involved in midbrain development	IDA IDA: 通过直接分析推断	14557550	MGI
involved in modulation of chemical synaptic transmission	EXP EXP: 通过实验结果推断	16501258	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	16501258	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: 通过突变表型推断	16501258	MGI
acts upstream of or within myoblast differentiation	IGI IGI: 通过遗传相互作用推断	19699733	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IDA IDA: 通过直接分析推断	18716223	MGI
involved in negative regulation of dopaminergic neuron differentiation	IDA IDA: 通过直接分析推断	14557550	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: 通过直接分析推断	15796911	MGI
acts upstream of or within negative regulation of fat cell differentiation	IGI IGI: 通过遗传相互作用推断	17888405	MGI
involved in negative regulation of neurogenesis	IDA IDA: 通过直接分析推断	12843296	MGI
involved in negative regulation of neuron projection development	IDA IDA: 通过直接分析推断	21539518	MGI
involved in neurogenesis	IDA IDA: 通过直接分析推断	14557550	MGI
involved in non-canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	17244647	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: 通过遗传相互作用推断	16581771	MGI
acts upstream of or within paraxial mesodermal cell fate commitment	IMP IMP: 通过突变表型推断	9126297	MGI
acts upstream of or within platelet activation	IDA IDA: 通过直接分析推断	19901330	MGI
acts upstream of or within platelet aggregation	IDA IDA: 通过直接分析推断	19901330	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: 通过直接分析推断	10933391	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	18929644	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	9356179	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17994217	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	18155657	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	19690384	MGI
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	17994217	MGI
acts upstream of or within positive regulation of cell-cell adhesion mediated by cadherin	IDA IDA: 通过直接分析推断	10893270	MGI
acts upstream of or within positive regulation of collateral sprouting in absence of injury	IDA IDA: 通过直接分析推断	18716223	MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	17251350	MGI
acts upstream of or within positive regulation of cytokine production	IDA IDA: 通过直接分析推断	23677472	MGI
acts upstream of or within positive regulation of hepatocyte proliferation	IDA IDA: 通过直接分析推断	23740243	MGI
acts upstream of or within positive regulation of neural precursor cell proliferation	IDA IDA: 通过直接分析推断	19896444	MGI
involved in positive regulation of protein localization to plasma membrane	IDA IDA: 通过直接分析推断	22899650	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	17027228	MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity	IGI IGI: 通过遗传相互作用推断	19920076	MGI
involved in positive regulation of skeletal muscle tissue development	IMP IMP: 通过突变表型推断	11856745	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	23740243	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	20371816	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	19699733	MGI
acts upstream of or within positive effect positive regulation of type B pancreatic cell proliferation	IDA IDA: 通过直接分析推断	17994217	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: 通过突变表型推断	8299937	MGI
acts upstream of or within protein localization	IDA IDA: 通过直接分析推断	17606995	MGI
acts upstream of or within regulation of RNA biosynthetic process	IDA IDA: 通过直接分析推断	22665494	MGI
acts upstream of or within regulation of axonogenesis	IGI IGI: 通过遗传相互作用推断	18716223	MGI
acts upstream of or within regulation of cell differentiation	IDA IDA: 通过直接分析推断	12717450	MGI
acts upstream of or within regulation of microtubule cytoskeleton organization	IGI IGI: 通过遗传相互作用推断	18716223	MGI
involved in regulation of postsynapse to nucleus signaling pathway	EXP EXP: 通过实验结果推断	16501258	MGI
involved in regulation of postsynapse to nucleus signaling pathway	IDA IDA: 通过直接分析推断	16501258	MGI
acts upstream of or within skeletal muscle cell differentiation	IGI IGI: 通过遗传相互作用推断	19699733	MGI
acts upstream of or within somatic stem cell division	IDA IDA: 通过直接分析推断	12717450	MGI
acts upstream of or within somitogenesis	IMP IMP: 通过突变表型推断	8299937	MGI
acts upstream of or within spinal cord association neuron differentiation	IDA IDA: 通过直接分析推断	11877374	MGI
acts upstream of or within spinal cord association neuron differentiation	IGI IGI: 通过遗传相互作用推断	11877374	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	19699733	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	8167409	MGI
located in extracellular space	IDA IDA: 通过直接分析推断	12897152	MGI
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	16501258	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	16501258	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	16501258	MGI
is active in synapse	IDA IDA: 通过直接分析推断	16501258	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

protein Wnt-3a

vestigial tail

wingless-related MMTV integration site 3A

Wnt3a 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Wnt3a	P27467	AFM	Homo sapiens	P43652	GMS	26902720
种属内	Wnt3a	P27467	AFM	Homo sapiens	P43652	Anti Tag CoIP	26902720
种属间	Wnt3a	P27467	LRP6	Homo sapiens	O75581	Comig Non-Denat Gel	23791946
种属内	Wnt3a	P27467	Fzd8	Mus musculus	Q61091	Pull Down	31036956
种属内	Wnt3a	P27467	Fzd8	Mus musculus	Q61091	Anti Tag CoIP	31036956
种属间	Wnt3a	P27467	WIF1	Homo sapiens	Q9Y5W5	Competition Binding	22986341
种属间	Wnt3a	P27467	TRABD2B	Homo sapiens	A6NFA1	Protease Assay	22726442
种属内	Wnt3a	P27467	Ptpro	Mus musculus	E9Q612	Anti Tag CoIP	20804755
种属内	Wnt3a	P27467	Ptpro	Mus musculus	E9Q612	Crosslink	20804755
种属间	Wnt3a	P27467	AFM	Bos taurus	G3MYZ3	Anti Tag CoIP	26902720

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	Phase
HY-153855	Zamaporvint	Inhibitor	99.76%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-129079A	TFMB-(S)-2-HG	Inhibitor	99.79%	否
HY-122832	ABC99	Inhibitor	98.48%	否
HY-160709	Wnt/β-catenin-IN-2	Inhibitor	/	否
HY-P10204	FZD7 antagonist 1		/	否
HY-RS15835	WNT3A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16706	Wnt3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23141	Wnt3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990841	Anti-pan-Glypican Antibody (HS20)	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Wnt3a	NCBI	NCBI:89780

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Wnt3a - wingless-type MMTV integration site family, member 3A Gene

关于 Wnt3a

功能概要

Wnt3a 基因产物(1)

Wnt3a 蛋白互作信息

直系同源

热门区域

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Wnt3a - wingless-type MMTV integration site family, member 3A Gene

关于 Wnt3a

功能概要

Wnt3a 基因产物(1)

Wnt3a 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z