WIF1 - WNT inhibitory factor 1 Gene

中文名称：WNT 抑制因子 1

种属: Homo sapiens

同用名: WIF-1

基因 ID: 11197 | 基因类型: protein coding

关于 WIF1

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:65,050,626-65,121,305 (from NCBI)

This gene has 3 transcripts (splice variants), 169 orthologues, 8 paralogues and is associated with 60 phenotypes. Biased expression in lung (RPKM 69.2), brain (RPKM 9.8) and 3 other tissues.

功能概要

由该基因编码的蛋白质可抑制 Wnt 蛋白，Wnt 蛋白是在胚胎发育中发挥作用的细胞外信号分子。这种蛋白质包含一个 Wnt 抑制因子 (WIF) 结构域和五个表皮生长因子 (EGF) 样结构域，并且被认为与中胚层分割有关。该基因作为肿瘤抑制基因发挥作用，并已被发现在各种癌症中被表观遗传沉默。[RefSeq 提供，2010 年 6 月]

The protein encoded by this gene functions to inhibit Wnt proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a Wnt inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

WIF1 基因产物(1)

mRNA	Protein	Name
NM_007191.5	NP_009122.2	wnt inhibitory factor 1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19188438	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WIF1 蛋白结构

WIF

hEGF

0
100
200
300
379 a.a.

蛋白主名

其他名称

wnt inhibitory factor 1

WIF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WIF1	Q9Y5W5	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
种属内	WIF1	Q9Y5W5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
种属内	WIF1	Q9Y5W5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
种属内	WIF1	Q9Y5W5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
种属间	WIF1	Q9Y5W5	Wnt5a	Mus musculus	P22725	SPR	22986341
种属间	WIF1	Q9Y5W5	Wnt5a	Mus musculus	P22725	Competition Binding	22986341
种属间	WIF1	Q9Y5W5	Wnt3a	Mus musculus	P27467	Competition Binding	22986341
种属间	WIF1	Q9Y5W5	Wnt3a	Mus musculus	P27467	SPR	22986341
种属间	WIF1	Q9Y5W5	Wnt3a	Mus musculus	P27467	SPR	21743455
种属内	WIF1	Q9Y5W5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
种属内	WIF1	Q9Y5W5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
种属内	WIF1	Q9Y5W5	WNT5A	Homo sapiens	P41221	SPR	26342861
种属内	WIF1	Q9Y5W5	WNT7A	Homo sapiens	O00755	SPR	22986341
种属内	WIF1	Q9Y5W5	WNT7A	Homo sapiens	O00755	SPR	26342861

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 WIF1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70982	WIF-1 Protein, Human (HEK293, His)	AAH18037.1 (G29-W379)	≥95%

WIF1 抗体

目录号	产品名	应用	反应物种
HY-P82919	WIF1 Antibody (YA2664)	WB, IP	Human, Mouse, Rat
HY-P83228	Wnt2 Antibody (YA2973)	WB	Human, Mouse, Rat
HY-P84898	WIF1 Antibody (YA4595)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P85408	WIF1 Antibody (YA5100)	WB, IHC-P, ICC/IF, ELISA	Human

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Squamous Cell Papilloma

Papilloma	Epidermoid Papilloma
Papilloma, Squamous Cell

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Spinocerebellar Ataxia 44

SCA44

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15816	WIF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18157	Wif1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24631	Wif1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	WIF1	VGNC	VGNC:48409
Felis catus	WIF1	VGNC	VGNC:67072
Mus musculus	WIF1	MGD	MGI:1344332
Bos taurus	WIF1	VGNC	VGNC:36938
Rattus norvegicus	WIF1	RGD	RGD:619774
Macaca mulatta	WIF1	VGNC	VGNC:79110
Others	WIF1	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

WIF1 - WNT inhibitory factor 1 Gene

关于 WIF1

功能概要

WIF1 基因产物(1)

WIF1 蛋白结构

WIF1 蛋白互作信息

重组 WIF1 蛋白

WIF1 抗体

关联疾病

直系同源

热门区域

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WIF1 - WNT inhibitory factor 1 Gene

关于 WIF1

功能概要

WIF1 基因产物(1)

WIF1 蛋白结构

WIF1 蛋白互作信息

重组 WIF1 蛋白

WIF1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z