Raf1 - Raf-1 proto-oncogene, serine/threonine kinase Gene

中文名称：Raf-1 原癌基因， 丝氨酸/苏氨酸激酶

种属: Rattus norvegicus

关于 Raf1

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；腺苷酸环化酶激活剂活性；和酶结合活性。涉及多个进程，包括MAPK级联；蛋白质磷酸化；和对缺氧的反应。位于细胞质和质膜中。胰腺癌的生物标志物。该基因的人类直系同源物与努南综合征有关（多个）； Noonan 综合征伴多发雀斑 2；腺癌（多发性）；和扩张型心肌病 1NN。与人 RAF1 同源（Raf-1 原癌基因，丝氨酸/苏氨酸激酶）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; Adenylate Cyclase Activator activity; and Enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]