2. MAPK/ERK Pathway
  3. Raf
  4. R18

R18  (Synonyms: PHCVPRDLSWLDLEANMCLP)

目录号: HY-P1039
产品使用指南

摩尔计算器

R18 是 14-3-3 的肽拮抗剂，其 KD 值为 70-90 nM。R18 可有效阻断 14-3-3 与其配体 Raf-1激酶的结合，可有效地消除 14-3-3 对磷酸酶诱导的 Raf-1 失活的保护作用。

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Custom Peptide Synthesis

R18 Chemical Structure

R18 Chemical Structure

CAS No. : 211364-78-2

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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R18 的其他形式现货产品:

Customer Review

Other Forms of R18:

R18 相关抗体

Top Publications Citing Use of Products

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BRaf c-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R18 is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].

分子量

2309.69

Formula

C101H157N27O29S3
CAS 号
Sequence

Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro
Sequence Shortening

PHCVPRDLSWLDLEANMCLP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R18211364-78-2PHCVPRDLSWLDLEANMCLPR 18R-18RafRaf kinasesInhibitorinhibitorinhibit

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