2. MAPK/ERK Pathway Apoptosis
  3. Raf Apoptosis
  4. RRD-251

RRD-251 是一种视网膜母细胞瘤肿瘤抑制蛋白 (Rb)-Raf-1相互作用 (Rb-Raf-1 interaction) 的抑制剂，具有高效的抗增殖、抗血管生成和抗肿瘤活性。

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RRD-251 Chemical Structure

RRD-251 Chemical Structure

CAS No. : 72214-67-6

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Customer Review

RRD-251 相关抗体

Top Publications Citing Use of Products

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BRaf c-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities[1].

IC50 & Target

Rb-Raf-1 interaction, apoptosis[1]
体外研究
(In Vitro)

RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro[1].
RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells[1].
RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours)[1].
RRD-251 alters the expression of cell cycle and apoptosis regulatory protein[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RRD-251 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
Concentration: 10 μM, 20 μM, 50 μM
Incubation Time: 24 hours
Result: Inhibited melanoma growth in-vitro.

Western Blot Analysis[1]

Cell Line: SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
Concentration: 50 μM
Incubation Time: 2 hours
Result: Showed the depletion of phosphorylated-Rb in RRD-251 treated cells.

Apoptosis Analysis[1]

Cell Line: SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
Concentration: 50 μM
Incubation Time: 18 hours
Result: Induced apoptosis.

Cell Cycle Analysis[1]

Cell Line: SK-MEL-28 cells , SK-MEL-5 cells
Concentration: 20 μM, 50 μM
Incubation Time: 4 hours
Result: Resulted in a dose dependent inhibition of cell cycle progression in SK-MEL-28 and SK-MEL-5 cells, respectively.
体内研究
(In Vivo)

RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-wk-old female athymic nude mice, with SK-ME-28 xenograft[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal administration, qod, for 14 days
Result: Inhibits the growth of SK-ME-28 xenograft in nude mice.
分子量

271.59

Formula

C8H9Cl3N2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (460.25 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6820 mL 18.4101 mL 36.8202 mL
5 mM 0.7364 mL 3.6820 mL 7.3640 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.94%

COA (168 KB) HNMR (248 KB) LCMS (257 KB)

产品使用指南 (1538 KB)
参考文献

RRD-251 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6820 mL 18.4101 mL 36.8202 mL 92.0505 mL
5 mM 0.7364 mL 3.6820 mL 7.3640 mL 18.4101 mL
10 mM 0.3682 mL 1.8410 mL 3.6820 mL 9.2051 mL
15 mM 0.2455 mL 1.2273 mL 2.4547 mL 6.1367 mL
20 mM 0.1841 mL 0.9205 mL 1.8410 mL 4.6025 mL
25 mM 0.1473 mL 0.7364 mL 1.4728 mL 3.6820 mL
30 mM 0.1227 mL 0.6137 mL 1.2273 mL 3.0684 mL
40 mM 0.0921 mL 0.4603 mL 0.9205 mL 2.3013 mL
50 mM 0.0736 mL 0.3682 mL 0.7364 mL 1.8410 mL
60 mM 0.0614 mL 0.3068 mL 0.6137 mL 1.5342 mL
80 mM 0.0460 mL 0.2301 mL 0.4603 mL 1.1506 mL
100 mM 0.0368 mL 0.1841 mL 0.3682 mL 0.9205 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RRD-25172214-67-6RRD251RRD 251RafApoptosisRaf kinasesmelanomaanticancerretinoblastomatumorsuppressorproteinRb-Raf-1Inhibitorinhibitorinhibit

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目录号：
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