2. Gene
  3. Pak1 - p21 (RAC1) activated kinase 1 Gene

Pak1 - p21 (RAC1) activated kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：p21 (RAC1) 激活激酶 1

种属: Rattus norvegicus

基因 ID: 29431 | 基因类型: protein coding

关于 Pak1

Primary_assembly 1: 152,111,188-152,226,383 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 216 orthologues, 36 paralogues and is associated with 20 phenotypes. Biased expression in Brain (RPKM 564.9), Adrenal (RPKM 131.3) and 7 other tissues.

功能概要

该基因编码的蛋白可启动蛋白激酶结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括参与心肌细胞发育的细胞生长的负调节；神经系统发育；和细胞迁移的正调控。位于多个细胞成分中，包括 Z 盘；闰盘;和荷叶边。脑缺血的生物标志物。该基因与乳腺癌相关的人类直向同源基因；肾细胞癌；和精神分裂症。与人 PAK1（p21 (RAC1) 激活激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pak1 基因产物(1)

mRNA Protein Name
NM_017198.2 NP_058894.1 serine/threonine-protein kinase PAK 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11895474 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
15542607 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
18054038 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12237306 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
8702668 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
20395366 RGD
involved in establishment of cell polarity IMP
IMP: 通过突变表型推断
20395366 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: 通过突变表型推断
22082674 RGD
involved in neuron projection morphogenesis IMP
IMP: 通过突变表型推断
9451000 RGD
involved in positive regulation of axon extension IMP
IMP: 通过突变表型推断
23453953 RGD
involved in positive regulation of fibroblast migration IDA
IDA: 通过直接分析推断
18931661 RGD
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
25199455 RGD
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
23453953 RGD
involved in positive regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
25199455 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
19901155 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
19901155 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
15542607 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
12237306 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
18347024 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
9367856 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
14670848 RGD
located in axon IDA
IDA: 通过直接分析推断
17687038 RGD
located in dendrite IDA
IDA: 通过直接分析推断
17687038 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
14670848 RGD
located in lamellipodium IDA
IDA: 通过直接分析推断
19574218 RGD
located in nuclear membrane IDA
IDA: 通过直接分析推断
14670848 RGD
located in ruffle IDA
IDA: 通过直接分析推断
19574218 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pak1 蛋白结构

PBD

PBD: pfam00786 (73 - 131)

STKc_PAK1

STKc_PAK1: cd06654 (247 - 542)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PAK 1

PAK-1

alpha-PAK

p21 (CDKN1A)-activated kinase 1

p21 protein (Cdc42/Rac)-activated kinase 1

p21-activated kinase 1

p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)

p68-PAK

protein kinase MUK2

Pak1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Pak1 P35465 Vim Mus musculus P20152
Protein Kinase Assay
11895474
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12005 Fingolimod hydrochloride Activator 99.94% 是
HY-15027 5-Aminosalicylic Acid Inhibitor 99.97% 否
HY-11063 Fingolimod Activator 99.97% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15663 IPA-3 Inhibitor 99.39% 否
HY-15542A FRAX597 Inhibitor 99.36% 否
HY-15542B FRAX486 Inhibitor 97.03% 否
HY-19635 G-5555 Inhibitor 99.88% 否
HY-120940 AZ13705339 Inhibitor 98.57% 否
HY-19635A G-5555 hydrochloride Inhibitor 98.26% 否
HY-19538 FRAX1036 Inhibitor 99.49% 否
HY-131043 NVS-PAK1-C Inhibitor 99.2% 否
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% 否
HY-131265 Mesalamine impurity P Inhibitor / 否
HY-146681 PAK1-IN-1 Inhibitor / 否
HY-146786 ZMF-10 Inhibitor / 否
HY-13007B PF-3758309 dihydrochloride Inhibitor / 否
HY-13007A PF-3758309 hydrochloride Inhibitor / 否
HY-116917 G-9791 Inhibitor / 否
HY-110085 2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Inhibitor 98.49% 否
HY-146783 ZINC194100678 Inhibitor / 否
HY-159897 PAK4-IN-5 Inhibitor / 否
HY-164374 AK963/40708899 Inhibitor / 否
HY-176539 PAK1-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pak1 NCBI NCBI:5058
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z