2. Cell Cycle/DNA Damage Cytoskeleton
  3. PAK
  4. PAK1-IN-1

PAK1-IN-1 是一种有效的选择性 PAK1 抑制剂，IC50 为 9.8 nM。PAK1-IN-1以剂量依赖性方式抑制 PAK1 相关肿瘤细胞的迁移和侵袭。

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PAK1-IN-1 Chemical Structure

PAK1-IN-1 Chemical Structure

CAS No. : 2485732-30-5

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PAK1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 PAK 亚型特异性产品:

查看所有亚型
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

IC50 & Target[1]

PAK1

9.8 nM (IC50)

PAK4

>10 μM (IC50)

体外研究
(In Vitro)

PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAK1-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT-116 cells
Concentration: 1 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10, 20 µM
Incubation Time: 1, 24 h
Result: Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.
分子量

469.92

Formula

C26H20ClN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAK1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAK1-IN-12485732-30-5PAKp21 activated kinaseslow cytotoxicityanticancerSnailMDA-MB-231HCT-116 cellsanti-migrationinvasionInhibitorinhibitorinhibit

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产品名称：
PAK1-IN-1
目录号：
HY-146681
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