PALM - paralemmin Gene

中文名称：副柠檬酸

种属: Homo sapiens

同用名: PALM1

基因 ID: 5064 | 基因类型: protein coding

关于 PALM

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:708,935-748,329 (from NCBI)

This gene has 11 transcripts (splice variants), 235 orthologues and 3 paralogues. Broad expression in fat (RPKM 28.7), brain (RPKM 22.8) and 18 other tissues.

功能概要

该基因编码副林明蛋白家族的一个成员。该基因的产物是一种异戊二烯化和棕榈酰化磷蛋白，它与质膜的细胞质面相关，并与神经元和其他细胞类型的质膜动力学有关。已经确定了几种可变剪接的转录本变体，但只有两个转录本变体的全长性质已经确定。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and Other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

PALM 基因产物(2)

mRNA	Protein	Name
NM_001040134.2	NP_001035224.1	paralemmin-1 isoform 2
NM_002579.3	NP_002570.2	paralemmin-1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16386234	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of dopamine receptor signaling pathway	IDA IDA: 通过直接分析推断	16386234	GOA
involved in positive regulation of filopodium assembly	IDA IDA: 通过直接分析推断	14978216	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in filopodium membrane	IDA IDA: 通过直接分析推断	14978216	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	16386234	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PALM 蛋白结构

Paralemmin

0
100
200
300
387 a.a.

蛋白主名

其他名称

paralemmin-1

PALM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PALM	O75781	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	PALM	O75781	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	PALM	O75781	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Osteopetrosis, Autosomal Dominant 2

OPTA2	Autosomal Dominant Osteopetrosis 2
Osteopetrosis Autosomal Dominant Type 2	Osteopetrosis, Autosomal Dominant, Type Ii
Albers-Schonberg Osteopetrosis	Autosomal Dominant Albers-Schonberg Disease
Osteopetrosis	Marble Bones, Autosomal Dominant
Osteosclerosis Fragilis Generalisata	Albers-Schonberg Disease, Autosomal Dominant
Autosomal Dominant Osteopetrosis Type Ii	Albers-Schönberg Osteopetrosis
Autosomal Dominant Osteopetrosis Type 2	Marble Disease Autosomal Dominant
Osteopetrosis, Autosomal Dominant, Type 2

Pettigrew Syndrome

PGS	Mrxs5
Mrx59	Mrxs21
X-Linked Intellectual Disability-Dandy-Walker Malformation-Basal Ganglia Disease-Seizures Syndrome	Mental Retardation, X-Linked, Syndromic 5
Mrxsf	Syndromic X-Linked Intellectual Disability 5
Fried Syndrome	Mental Retardation, X-Linked Syndromic 5
Mental Retardation, X-Linked, With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures	Mental Retardation, X-Linked, Syndromic, Fried Type
Mental Retardation, X-Linked, Syndromic 21	Syndromic X-Linked Mental Retardation 21
Syndromic X-Linked Mental Retardation Fried Type	X-Linked Metal Retardation With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures
Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease An	Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease And Seizures
X-Linked Syndromic Intellectual Disability 5	X-Linked Intellectual Disability With Dandy-Walker Malformation Basal Ganglia Disease And Seizures
X-Linked Intellectual Disability - Dandy-Walker Malformation - Basal Ganglia Disease - Seizures	X-Linked Intellectual Disability-Hypotonia-Facial Dysmorphism-Aggressive Behavior Syndrome
Mental Retardation, X-Linked Syndromic, Fried Type	Dandy-Walker Malformation With Mental Retardation, Basal Ganglia Disease, And Seizures
Mental Retardation, X-Linked 59

Differentiating Neuroblastoma

Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii	Isolated Growth Hormone Deficiency Type Ii
IGHD2	Growth Hormone Deficiency, Isolated, Type Ii
Congenital Ighd Type Ii	Congenital Isolated Gh Deficiency Type Ii
Congenital Isolated Growth Hormone Deficiency Type Ii	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant
Growth Hormone Deficiency, Isolated, Autosomal Dominant	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant
Autosomal Dominant Isolated Growth Hormone Deficiency	Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 2	Growth Hormone Deficiency, Isolated Autosomal Dominant
Growth Hormone Deficiency, Isolated, 2	Growth Hormone Deficiency Isolated Autosomal Dominant

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase

生物活性分子 (2)

目录号	产品名	作用方式	纯度	Phase
HY-P10031A	SAR441255 TFA	Agonist	99.93%	Phase 1
HY-P10031	SAR441255	Agonist	99.77%	Phase 1

Pre-clinical Phase

生物活性分子 (41)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N2041	Myristic acid		≥98.0%	否
HY-N0773	Isovitexin	Inhibitor	99.77%	否
HY-N2041S	Myristic acid-d27		98.83%	否
HY-108693	β-Tocotrienol	Inducer	98.89%	否
HY-P10932A	pGk13a TFA		/	否
HY-N2041S3	Myristic acid-d3		98.62%	否
HY-N2041S6	Myristic acid-d5		≥98.0%	否
HY-P0064	Palmitoyl Tetrapeptide-3	Inhibitor	99.20%	否
HY-D1196	Direct Blue 71		/	否
HY-148702	di-Pal-MTO		98.37%	否
HY-N2041S7	Myristic acid-d7		99.80%	否
HY-W013788	2-Palmitoylglycerol	Agonist	≥99.0%	否
HY-133535	PA Janelia Fluor® 646, SE		99.0%	否
HY-145519	Mu-6S-Palm-β-Glc		98.40%	否
HY-W099600	Lauric anhydride		≥97.0%	否
HY-B0828	Triazophos	Inhibitor	98.70%	否
HY-W250170	Decyl glucoside (60% in water)		/	否
HY-120634	BMS-929075	Inhibitor	/	否
HY-128430	Farnesyl acetate	Inhibitor	/	否
HY-148701	mono-Pal-MTO		/	否
HY-157172	MorHap	Inhibitor	/	否
HY-170223	Palm oil		/	否
HY-N2041S1	Myristic acid-d2		/	否
HY-N2041S4	Myristic acid-13C3		/	否
HY-N2041S5	Myristic acid-d1		/	否
HY-N7813	1,2-Dipalmitoyl-3-oleoylglycerol		/	否
HY-P10379	palm-PrRP31	Agonist	/	否
HY-P10380	palm11-PrRP31	Agonist	/	否
HY-RS10005	PALM Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS10006	PALM2AKAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS10007	PALM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W010736A	1,2-Dipalmitoyl-rac-glycerol		/	否
HY-W750719	Neurosporene		/	否
HY-10467	HCV-796 analog	Inhibitor	/	否
HY-N2041S2	Myristic acid-13C		/	否
HY-P10932	pGk13a		/	否
HY-RS18489	Palm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24971	Palm Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W010667	(Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate		/	否
HY-W710399	2-Hydroxy-3-(palmitoyloxy)propyl stearate		/	否
HY-W710976	4-Methyl-5-nonanone		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PALM	VGNC	VGNC:32558
Macaca mulatta	PALM	VGNC	VGNC:75751
Felis catus	PALM	VGNC	VGNC:102653
Canis familiaris	PALM	VGNC	VGNC:54980
Rattus norvegicus	PALM	RGD	RGD:620341
Mus musculus	PALM	MGD	MGI:1261814
Others	PALM	NCBI

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