2. Gene
  3. PSD - pleckstrin and Sec7 domain containing Gene

PSD - pleckstrin and Sec7 domain containing Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 pleckstrin 和 Sec7 结构域

种属: Homo sapiens

同用名: TYL; EFA6; PSD1; EFA6A

基因 ID: 5662 | 基因类型: protein coding

关于 PSD

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,402,619-102,419,946 (from NCBI)

This gene has 9 transcripts (splice variants), 297 orthologues and 15 paralogues. Biased expression in brain (RPKM 23.5), endometrium (RPKM 9.6) and 8 other tissues.

功能概要

该基因编码 Plekstrin 同源性和包含 SEC7 结构域的蛋白质，该蛋白质起鸟嘌呤核苷酸交换因子的作用。编码的蛋白质通过激活 ADP-核糖基化因子 6 来调节信号转导。可变剪接导致多个转录变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

PSD 基因产物(3)

mRNA Protein Name
NM_001270965.2 NP_001257894.1 PH and SEC7 domain-containing protein 1 isoform 1
NM_001270966.2 NP_001257895.1 PH and SEC7 domain-containing protein 1 isoform 2
NM_002779.5 NP_002770.3 PH and SEC7 domain-containing protein 1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
23603394 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20339350 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cleavage furrow IDA
IDA: 通过直接分析推断
23603394 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
23603394 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSD 蛋白结构

Sec7

Sec7: Sec7 domain (549 - 707)

PH_9

PH_9: Pleckstrin homology domain (758 - 869)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1024 a.a.
蛋白主名 其他名称

PH and SEC7 domain-containing protein 1

exchange factor for ADP-ribosylation factor guanine nucleotide factor 6

PSD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
PSD A5PKW4 Usp9x Mus musculus P70398
Pull Down
20339350
种属间
PSD A5PKW4 Usp9x Mus musculus P70398
IF
20339350
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P0117 Tat-NR2B9c Inhibitor 99.77% Phase 3
Pre-clinical Phase
生物活性分子 (27)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100456 ZL006 Inhibitor 99.23% 否
HY-W009118 Fmoc-5-Ava-OH 99.49% 否
HY-100457 IC87201 Inhibitor 97.24% 否
HY-117772 FSC231 Inhibitor 99.84% 否
HY-P0117A Tat-NR2B9c TFA Inhibitor 99.66% 否
HY-146885S 16:0-18:1 PS-d31 sodium 99.08% 否
HY-P1195 PDZ1 Domain inhibitor peptide 99.04% 否
HY-P2307 Tat-NR2Baa 96.89% 否
HY-143675S 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9 / 否
HY-145539S 12-Dipalmitoyl-sn-glycero-3-PS-d62 sodium salt 99.0% 否
HY-155355 LY836 Inhibitor / 否
HY-175824 PSD-95/nNOS PPI-IN-1 Inhibitor / 否
HY-176866 Rodin-A Inhibitor / 否
HY-176867 Rodin-B Inhibitor / 否
HY-P10212 AVLX-125 Inhibitor / 否
HY-P1195A PDZ1 Domain inhibitor peptide TFA / 否
HY-P2307A Tat-NR2Baa TFA / 否
HY-RS10573 PISD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11272 PSD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11273 PSD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11274 PSD3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11275 PSD4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-167592S 17:0-20:3 PS-d5 / 否
HY-21197 Perfluoroenanthic acid / 否
HY-P10401 TAT-GluR6-9c Antagonist / 否
HY-RS18221 Psd Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24698 Psd Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PSD VGNC VGNC:45082
Rattus norvegicus PSD RGD RGD:620297
Mus musculus PSD MGD MGI:1920978
Felis catus PSD VGNC VGNC:69099
Bos taurus PSD VGNC VGNC:107303
Others PSD NCBI
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