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  4. FSC231

FSC231 是 PICK1 的 PSD-95/DLG/ZO-1 (PDZ) 结构域抑制剂。FSC231 具有镇痛作用。

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FSC231 Chemical Structure

FSC231 Chemical Structure

CAS No. : 1215849-96-9

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FSC231 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects[1].

IC50 & Target

PICK1[1].
体外研究
(In Vitro)

FSC231 (50 μM) 阻断 COS7 细胞中 GluR2 与 PICK1 之间的结合[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FSC231 相关抗体:
体内研究
(In Vivo)

FSC231 (总共 78.40 μg/kg，每日，腹腔注射七次，紫杉醇给药前 3 小时) 可减轻紫杉醇 (HY-B0015) 诱导的大鼠神经痛[1]。
FSC231 (39.2 μg/kg/天，腹腔注射，持续 4 周) 部分通过 PICK1/eNOS/cGMP 通路抑制 ROS 生成和细胞凋亡，从而抑制大鼠糖尿病心肌病的发展[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Paclitaxel (HY-B0015)‐induced neuralgia of rats[1]
Dosage: 78.40 μg/kg in total
Administration: i.p., daily, seven times, completed at 3 h before Paclitaxel
Result: Reversed the changes of inflammatory cytokines (IL‐6, TNF‐α and IL‐10).
Inhibited the phosphorylation levels of GSK‐3β and ERK1/2.
分子量

313.14

Formula

C13H10Cl2N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FSC231 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSC2311215849-96-9FSC 231FSC-231Othersneuralgiadiabetic cardiomyopathyCOS7Inhibitorinhibitorinhibit

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目录号：
HY-117772
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