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  3. Tat-NR2Baa TFA

Tat-NR2Baa TFA 

目录号: HY-P2307A

Tat-NR2BAA TFA 是 Tat-NR2B9c (HY-P0117) 的对照肽 (control peptide),没有活性。Tat-NR2BAA TFA 的序列与 Tat-NR2B9c 相似,但在 COOH 末端 tSXV 基序中有一个双点突变,这使得它无法结合 PSD-95。Tat-NR2B9c TFA 是一种可通透细胞膜的多肽,破坏 PSD-95/NMDAR 的结合。

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Tat-NR2Baa TFA Chemical Structure

Tat-NR2Baa TFA Chemical Structure

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Tat-NR2Baa TFA 的其他形式现货产品:

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Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95[1].

IC50 & Target

NMDA Receptor


(In Vitro)

Tat-NR2BAA TFA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue[1].
Tat-NR2BAA TFA (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell.But Tat-NR2BAA TFA has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c (HY-P0117)[1].
Tat-NR2BAA TFA (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.







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Tat-NR2Baa TFA