PTPRA - protein tyrosine phosphatase receptor type A Gene

中文名称：A 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha

关于 PTPRA

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 包含一个细胞外结构域、一个跨膜区段和两个串联的胞质内催化结构域，因此代表受体型 PTP。该 PTP 已被证明可以去磷酸化和激活 Src 家族酪氨酸激酶，并且与整合素信号传导、细胞粘附和增殖的调节有关。已经报道了该基因的三种可变剪接变体，它们编码两种不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of Integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]