1. 重组蛋白
  2. Receptor Proteins Enzymes & Regulators
  3. Receptor Tyrosine Phosphatase Phosphatase
  4. Protein tyrosine phosphatases
  5. PTP alpha
  6. PTP alpha/PTPRA 蛋白, Human (sf9, His-GST)

PTP alpha/PTPRA 蛋白, Human (sf9, His-GST)

目录号: HY-P76555
产品使用指南

PTP α/PTPRA 蛋白是一种酪氨酸蛋白磷酸酶,参与整合素介导的粘着斑形成。整合素参与后,它会将 BCAR3、BCAR1 和 CRK 募集至粘着斑,促进 SRC 介导的 BRAC1 磷酸化。这导致 PAK 和小 GTPases RAC1 和 CDC42 的激活。PTP alpha/PTPRA 蛋白, Human (sf9, His-GST) 是重组的 PTP α/PTPRA 蛋白,由 Sf9 insect cells 表达,带有 N-His, N-GST 标签。PTP alpha/PTPRA 蛋白, Human (sf9, His-GST) 全长 620 个氨基酸,分子量约为 ~90 kDa。

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规格 价格 是否有货
5 μg ¥800 询问价格 & 货期
10 μg ¥1360 询问价格 & 货期
50 μg ¥3800 询问价格 & 货期
100 μg ¥6460 询问价格 & 货期

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描述

PTP alpha/PTPRA Protein, a tyrosine protein phosphatase, participates in integrin-mediated focal adhesion formation. Upon integrin engagement, it recruits BCAR3, BCAR1, and CRK to focal adhesions, promoting SRC-mediated phosphorylation of BRAC1. This leads to the activation of PAK and small GTPases RAC1 and CDC42. PTP alpha/PTPRA Protein, Human (sf9, His-GST) is the recombinant human-derived PTP alpha/PTPRA protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PTP alpha/PTPRA Protein, Human (sf9, His-GST) is 620 a.a., with molecular weight of ~90 kDa.

研究背景

PTP α/PTPRA 是一种酪氨酸蛋白磷酸酶,在整合素介导的粘着斑形成中发挥着关键作用。在整合素参与后,它选择性地将 BCAR3、BCAR1 和 CRK 募集至粘着斑,促进 SRC 介导的 BRAC1 磷酸化。该磷酸化事件激活涉及 PAK 以及小 GTPase RAC1 和 CDC42 的下游信号级联。通过参与这些复杂的分子过程,PTP α/PTPRA 有助于动态调节粘着斑,影响细胞对整合素信号传导的反应。

种属

Human

表达系统

Sf9 insect cells

标签

N-His;N-GST

蛋白编号

P18433-2 (A174-K793)

基因 ID
蛋白结构
N-term
His-GST
PTPRA (A174-K793)
Accession # P18433-2
C-term
同用名
Receptor-type tyrosine-protein phosphatase alpha; R-PTP-alpha; PTPA; PTPRL2
分子量

Approximately 90 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PTP alpha/PTPRA Protein, Human (sf9, His-GST)
目录号:
HY-P76555
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