1. Gene
  2. PTPRN - protein tyrosine phosphatase receptor type N Gene

PTPRN - protein tyrosine phosphatase receptor type N Gene

中文名称:N 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP

基因 ID: 5798 | 基因类型: protein coding

关于 PTPRN

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,289,623-219,309,401 (from NCBI)

This gene has 19 transcripts (splice variants), 258 orthologues and 35 paralogues. Biased expression in brain (RPKM 53.0), adrenal (RPKM 12.2) and 2 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有细胞外区域、单个跨膜区域和单个催化结构域,因此代表受体型 PTP。该 PTP 被发现是一种自身抗原,可与胰岛素依赖型糖尿病 (IDDM) 患者血清发生反应,因此可能是糖尿病自身免疫的潜在靶标。交替剪接导致多个转录变体。[RefSeq 提供,2010 年 12 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

PTPRN 基因产物(3)

mRNA Protein Name
NM_001199763.2 NP_001186692.1 receptor-type tyrosine-protein phosphatase-like N isoform 2 precursor
NM_001199764.2 NP_001186693.1 receptor-type tyrosine-protein phosphatase-like N isoform 3
NM_002846.4 NP_002837.1 receptor-type tyrosine-protein phosphatase-like N isoform 1 precursor

PTPRN 蛋白结构

RESP18

RESP18: RESP18 domain (60 - 155)

Receptor_IA-2

Receptor_IA-2: Protein-tyrosine phosphatase receptor IA-2 (469 - 558)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (734 - 968)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 979 a.a.
蛋白主名 其他名称

receptor-type tyrosine-protein phosphatase-like N

ICA 512

重组 PTPRN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70847 IA2 Protein, Human (293a.a, His) Q16849 (M687-Q979) ≥95%
HY-P70848 IA2 Protein, Human (365a.a, His) Q16849-2 (R576-Q950) ≥95%
HY-P70847A IA2 Protein, Human (293a.a, N-His) Q16849-1 (M687-Q979) ≥95%
HY-P70848A IA2 Protein, Human (365a.a, N-His) Q16849-2 (R576-Q950) ≥95%

关联疾病

疾病名称 别名
Insulinoma

Islet Cell Adenoma

Insulin-Producing Tumor Of Islet Cells

Adenoma Islet Cell

Islet Cell Tumor

Experimental Organism Islet Cell Adenoma Neoplasm

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications

Diabetes Mellitus

Diabetes

Gestational Diabetes

Gestational Diabetes Mellitus

GDM

Diabetes Mellitus Arising In Pregnancy

Maternal Gestational Diabetes Mellitus

Diabetes Mellitus, Gestational

Diabetes Mellitus, Pregnancy Related

Diabetes, Pregnancy-Induced

Diabetes Gestational

Diabetes, Gestational

Diabetes Of Pregnancy

Gdm - [Gestational Diabetes Mellitus]

Gestational Diabetes Mellitus Nos

Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Microinvasive Cervical Squamous Cell Carcinoma

Early Invasive Cervical Squamous Cell Carcinoma

Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5

Latent Autoimmune Diabetes In Adults

IDDM5

Insulin-Dependent Diabetes Mellitus 5

T1D5

Lada

Type 1.5 Diabetes

Diabetes Mellitus, Insulin-Dependent, Type 5

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Lymphocele

Lymph Cyst

Lymphocele Adverse Event

Common Peroneal Nerve Lesion

Lesion Of Lateral Popliteal Nerve

Fibular Neuropathy

Parametritis

Pelvic Cellulitis

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis

KPD

Diabetes Mellitus, Ketosis-Prone, Susceptibility To

Ketosis-Prone Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetic Ketoacidosis Nos

Dka - [Diabetic Ketoacidosis] Nos

Dka - [Diabetic Ketoacidosis] Without Coma

Dka - [Diabetic Ketoacidosis] With Coma

Hemometra

Hematometra

Cervical Incompetence

Uterine Cervical Incompetence

Type 1 Diabetes Mellitus 7

Diabetes Mellitus, Insulin-Dependent, 7

Iddm7

Insulin-Dependent Diabetes Mellitus 7

T1D7

Pancreatic Colloid Cystadenoma

Mucinous Cystadenoma Of Pancreas

Wissler-Fanconi Syndrome

Wissler'S Syndrome

Wissler'S Subsepsis Allergica

Isthmus Cancer
Cervical Large Cell Neuroendocrine Carcinoma
Autoimmune Disease Of Endocrine System
Adenocarcinoma In Situ
Adrenal Cortical Hypofunction

Adrenal Cortical Insufficiency

Corticoadrenal Insufficiency

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Adenosquamous Carcinoma

Adenosquamous Cell Carcinoma

Mixed Adenocarcinoma And Squamous Carcinoma

Carcinoma Adenosquamous

Carcinoma, Adenosquamous

Gastrointestinal System Benign Neoplasm
Uterus Carcinoma In Situ
Pernicious Anemia

Anemia, Pernicious

Anemia Pernicious

Pernicious Anaemia

Addison'S Anaemia

Biermer'S Anaemia

Biermer'S Anemia

Acquired Pernicious Anemia

Addison-Biermer Anemia

Addisonian Anemia

Biermer Anemia

Biermer'S Disease

Juvenile Onset Pernicious Anemia

Biermer Disease

Biermer-Addison Disease

Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix

Carcinoma In Situ Of Uterine Cervix

Cervical Intraepithelial Neoplasia

Carcinoma Of Cervix Stage 0

Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

Cervix Ca In Situ

Cin Iii

Cin Iii - Carcinoma In Situ Of Cervix

Cin Iii - Severe Dyskaryosis

Severe Dysplasia Of Cervix

Severe Dysplasia Of The Cervix Uteri

Squamous Intraepithelial Neoplasia, Grade Iii

Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Cervical Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Cervix

Adenosquamous Cell Carcinoma Of The Cervix Uteri

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset

Fallopian Tube Endometrioid Adenocarcinoma

Endometrioid Carcinoma Of The Fallopian Tube

Fallopian Tube Endometrioid Cancer

Fallopian Tube Endometrioid Neoplasm

Fallopian Tube Endometrioid Tumor

Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3

MODY3

Mody, Type Iii

Mody Type 3

Mody, Type 3

Maturity-Onset Diabetes Of The Young 3

Mody-3

Diabetes Of The Young, Maturity-Onset, Type 3

Cervix Carcinoma

Cancer Of Cervix

Carcinoma Of Cervix

Carcinoma Cervix Uteri

Carcinoma Of The Cervix Uteri

Permanent Neonatal Diabetes Mellitus

Pndm

Permanent Diabetes Mellitus Of Infancy

Pdmi

Neonatal Diabetes Mellitus, Permanent

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PTPRN RGD RGD:620777
Bos taurus PTPRN VGNC VGNC:33554
Canis familiaris PTPRN VGNC VGNC:45193
Macaca mulatta PTPRN VGNC VGNC:76620
Felis catus PTPRN VGNC VGNC:69178
Mus musculus PTPRN MGD MGI:102765
Others PTPRN NCBI