PTPRT - protein tyrosine phosphatase receptor type T Gene

中文名称：T 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: R-PTP-T; RPTPrho; RPTP-rho

关于 PTPRT

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有细胞外区域、单个跨膜区域和两个串联的细胞内催化结构域，因此代表受体型 PTP。细胞外区域包含安眠蛋白-A5 抗原-PTP (MAM) 结构域、Ig 样和纤连蛋白 III 型样重复序列。该 PTP 的小鼠对应物的蛋白质结构域结构和表达模式表明它在中枢神经系统的信号转导和细胞粘附中的作用。已经报道了该基因的两种选择性剪接的转录物变体，它们编码不同的蛋白质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]