Nfkbiz - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta Gene

种属: Mus musculus

同用名: INAP; Mail

基因 ID: 80859 | 基因类型: protein coding

关于 Nfkbiz

功能概要

Involved in T cell receptor signaling pathway and positive regulation of T-helper 17 cell differentiation. Acts upstream of or within inflammatory response. Located in nucleus. Is expressed in early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbiz 基因产物(3)

mRNA	Protein	Name
NM_001159394.1	NP_001152866.1	NF-kappa-B inhibitor zeta isoform a
NM_001159395.1	NP_001152867.1	NF-kappa-B inhibitor zeta isoform b
NM_030612.3	NP_085115.1	NF-kappa-B inhibitor zeta isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	20383124	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	25107474	MGI
enables transcription coregulator activity	IDA IDA: 通过直接分析推断	15618216	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in B cell proliferation	IMP IMP: 通过突变表型推断	23728777	MGI
involved in B cell receptor apoptotic signaling pathway	IDA IDA: 通过直接分析推断	23728777	MGI
involved in B cell receptor signaling pathway	IDA IDA: 通过直接分析推断	17367755	MGI
involved in T cell differentiation	IMP IMP: 通过突变表型推断	26019294	MGI
involved in T cell mediated immunity	IMP IMP: 通过突变表型推断	31182790	MGI
involved in T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	25282160	MGI
involved in T-helper 1 cell differentiation	IMP IMP: 通过突变表型推断	31182790	MGI
involved in T-helper 17 cell differentiation	IMP IMP: 通过突变表型推断	20383124	MGI
involved in adaptive immune response	IDA IDA: 通过直接分析推断	17367755	MGI
involved in cell growth	IMP IMP: 通过突变表型推断	28740238	MGI
involved in cellular response to cytokine stimulus	IDA IDA: 通过直接分析推断	32144162	MGI
involved in cellular response to cytokine stimulus	IMP IMP: 通过突变表型推断	26460049	MGI
involved in cellular response to interleukin-17	IDA IDA: 通过直接分析推断	31853061	MGI
involved in cellular response to interleukin-17	IMP IMP: 通过突变表型推断	31164412	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: 通过突变表型推断	27129283	MGI
involved in cellular response to transforming growth factor beta stimulus	IMP IMP: 通过突变表型推断	26019294	MGI
involved in chemokine production	IMP IMP: 通过突变表型推断	15491998	MGI
involved in chromatin organization	IMP IMP: 通过突变表型推断	18319258	MGI
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	27129283	MGI
involved in chromatin remodeling	IMP IMP: 通过突变表型推断	27129283	MGI
involved in chronic inflammatory response	IMP IMP: 通过突变表型推断	31853061	MGI
involved in cytokine production	IMP IMP: 通过突变表型推断	28740238	MGI
involved in cytokine-mediated signaling pathway	IMP IMP: 通过突变表型推断	30224457	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: 通过突变表型推断	31182790	MGI
involved in epithelial cell apoptotic process	IMP IMP: 通过突变表型推断	23453632	MGI
involved in establishment of skin barrier	IMP IMP: 通过突变表型推断	28740238	MGI
involved in execution phase of apoptosis	IMP IMP: 通过突变表型推断	26776679	MGI
involved in gene expression	IDA IDA: 通过直接分析推断	15618216	MGI
involved in gene expression	IMP IMP: 通过突变表型推断	15491998	MGI
involved in homeostasis of number of cells within a tissue	IMP IMP: 通过突变表型推断	26019294	MGI
involved in immunoglobulin mediated immune response	IMP IMP: 通过突变表型推断	25124037	MGI
involved in immunoglobulin production	IMP IMP: 通过突变表型推断	15491998	MGI
involved in immunoglobulin production involved in immunoglobulin-mediated immune response	IMP IMP: 通过突变表型推断	18441309	MGI
acts upstream of or within inflammatory response	IDA IDA: 通过直接分析推断	11086164	MGI
involved in inflammatory response	IMP IMP: 通过突变表型推断	15491998	MGI
involved in inflammatory response to wounding	IDA IDA: 通过直接分析推断	26776679	MGI
involved in interleukin-10 production	IMP IMP: 通过突变表型推断	27129283	MGI
involved in isotype switching	IMP IMP: 通过突变表型推断	25124037	MGI
involved in keratinocyte activation	IMP IMP: 通过突变表型推断	15491998	MGI
involved in keratinocyte differentiation	IMP IMP: 通过突变表型推断	26460049	MGI
involved in keratinocyte proliferation	IMP IMP: 通过突变表型推断	26460049	MGI
involved in lymphocyte activation involved in immune response	IMP IMP: 通过突变表型推断	23453632	MGI
involved in mRNA transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	27129283	MGI
involved in mRNA transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	27129283	MGI
involved in plasma cell differentiation	IMP IMP: 通过突变表型推断	25124037	MGI
involved in positive regulation of T-helper 17 cell differentiation	IMP IMP: 通过突变表型推断	25282160	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	27129283	MGI
involved in regulation of immune response	IMP IMP: 通过突变表型推断	26019294	MGI
involved in response to Gram-positive bacterium	IMP IMP: 通过突变表型推断	28740238	MGI
involved in response to cisplatin	IDA IDA: 通过直接分析推断	26776679	MGI
involved in response to cytokine	IMP IMP: 通过突变表型推断	26776679	MGI
involved in response to folic acid	IDA IDA: 通过直接分析推断	26776679	MGI
involved in response to lipopolysaccharide	IMP IMP: 通过突变表型推断	26776679	MGI
involved in response to xenobiotic stimulus	IMP IMP: 通过突变表型推断	31622280	MGI
involved in skin development	IMP IMP: 通过突变表型推断	15491998	MGI
involved in skin epidermis development	IMP IMP: 通过突变表型推断	15491998	MGI
involved in spleen development	IMP IMP: 通过突变表型推断	31182790	MGI
involved in toll-like receptor signaling pathway	IDA IDA: 通过直接分析推断	23728777	MGI
involved in toll-like receptor signaling pathway	IMP IMP: 通过突变表型推断	23728777	MGI
involved in transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	20383124	MGI
involved in transcription preinitiation complex assembly	IMP IMP: 通过突变表型推断	18319258	MGI
involved in type II interferon production	IMP IMP: 通过突变表型推断	26019294	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in nucleus	IDA IDA: 通过直接分析推断	15618216	MGI
located in nucleus	IDA IDA: 通过直接分析推断	11086164	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

NF-kappa-B inhibitor zeta

I-kappa-B-zeta	IL-1 inducible nuclear ankyrin-repeat protein
IkappaB-zeta	ikB-zeta
ikappaBzeta	molecule possessing ankyrin-repeats induced by lipopolysaccharide

Nfkbiz 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Nfkbiz	Q9EST8	Akirin2	Mus musculus	B1AXD8	Anti Tag CoIP	25107474
种属内	Nfkbiz	Q9EST8	Akirin2	Mus musculus	B1AXD8	Anti Bait CoIP	25107474

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09265	NFKBIZ Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Nfkbiz	NCBI	NCBI:64332

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