1. Gene
  2. FZD7 - frizzled class receptor 7 Gene

FZD7 - frizzled class receptor 7 Gene

中文名称:卷曲类受体 7

种属: Homo sapiens

同用名: FzE3

基因 ID: 8324 | 基因类型: protein coding

关于 FZD7

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,033,855-202,038,441 (from NCBI)

This gene has 1 transcript (splice variant), 265 orthologues and 15 paralogues.

功能概要

“frizzled”基因家族的成员编码 7 个跨膜结构域蛋白,这些蛋白是 Wnt 信号蛋白的受体。 FZD7 蛋白包含一个 N 端信号序列、10 个典型的 Fz 家族成员富含半胱氨酸的胞外结构域的半胱氨酸残基、7 个假定的跨膜结构域和一个带有 PDZ 结构域结合基序的胞内 C 端尾部。 FZD7 基因表达可能下调 APC 功能并增强低分化人食管癌中 β-连环蛋白介导的信号。[RefSeq 提供,2008 年 7 月]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

FZD7 基因产物(1)

mRNA Protein Name
NM_003507.2 NP_003498.1 frizzled-7 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
18256285 GOA
enables Wnt receptor activity IDA
IDA: 通过直接分析推断
28733458 GOA
enables Wnt-protein binding IPI
IPI: 通过物理相互作用推断
18313787 GOA
enables frizzled binding IPI
IPI: 通过物理相互作用推断
19188438 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
27386966 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
18215320 GOA
involved in canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
18313787 GOA
involved in mesenchymal to epithelial transition IMP
IMP: 通过突变表型推断
17016432 GOA
involved in negative regulation of cardiac muscle cell differentiation IGI
IGI: 通过遗传相互作用推断
23939491 GOA
involved in negative regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
18156211 GOA
involved in negative regulation of ectodermal cell fate specification IMP
IMP: 通过突变表型推断
18681827 GOA
involved in non-canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
19773752 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18215320 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19773752 GOA
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
19773752 GOA
involved in positive regulation of epithelial cell proliferation involved in wound healing IMP
IMP: 通过突变表型推断
18313787 GOA
involved in positive regulation of phosphorylation IDA
IDA: 通过直接分析推断
18256285 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18681827 GOA
involved in regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
9707618 GOA
involved in stem cell population maintenance IMP
IMP: 通过突变表型推断
18681827 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
18256285 GOA
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
27386966 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FZD7 蛋白结构

Fz

Fz: Fz domain (49 - 160)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (243 - 565)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
蛋白主名 其他名称

frizzled-7

Frizzled, drosophila, homolog of, 7

FZD7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FZD7 O75084 TMEM237 Homo sapiens Q96Q45-2 32296183
种属内
FZD7 O75084 TMEM237 Homo sapiens Q96Q45-2 32296183
种属内
FZD7 O75084 TMEM237 Homo sapiens Q96Q45-2 32296183
种属内
FZD7 O75084 SLC6A15 Homo sapiens Q9H2J7 32296183
种属内
FZD7 O75084 SLC6A15 Homo sapiens Q9H2J7 32296183
种属内
FZD7 O75084 SLC6A15 Homo sapiens Q9H2J7 32296183
种属内
FZD7 O75084 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
FZD7 O75084 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
FZD7 O75084 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
FZD7 O75084 SLC30A4 Homo sapiens O14863 32296183
种属内
FZD7 O75084 SLC30A4 Homo sapiens O14863 32296183
种属内
FZD7 O75084 AQP9 Homo sapiens O43315 32296183
种属内
FZD7 O75084 AQP9 Homo sapiens O43315 32296183
种属内
FZD7 O75084 LEUTX Homo sapiens A8MZ59 32296183
种属内
FZD7 O75084 LEUTX Homo sapiens A8MZ59 32296183
种属内
FZD7 O75084 MGST1 Homo sapiens P10620 32296183
种属内
FZD7 O75084 MGST1 Homo sapiens P10620 32296183
种属内
FZD7 O75084 MGST1 Homo sapiens P10620 32296183
种属内
FZD7 O75084 FFAR2 Homo sapiens O15552 32296183
种属内
FZD7 O75084 FFAR2 Homo sapiens O15552 32296183
种属内
FZD7 O75084 SGTA Homo sapiens O43765 32296183
种属内
FZD7 O75084 SGTA Homo sapiens O43765 32296183
种属内
FZD7 O75084 WNT3 Homo sapiens P56703 21314951
种属内
FZD7 O75084 WNT3 Homo sapiens P56703 18313787
种属内
FZD7 O75084 SDCBP Homo sapiens O00560 18256285
种属内
FZD7 O75084 SDCBP Homo sapiens O00560 18256285
种属内
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0 32296183
种属内
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0 16189514
种属内
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0 32296183
种属内
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0 32296183
种属内
FZD7 O75084 SGTB Homo sapiens Q96EQ0 32296183
种属内
FZD7 O75084 SGTB Homo sapiens Q96EQ0 32296183
种属内
FZD7 O75084 SGTB Homo sapiens Q96EQ0 32296183
种属内
FZD7 O75084 NCS1 Homo sapiens P62166 32296183
种属内
FZD7 O75084 NCS1 Homo sapiens P62166 32296183
种属内
FZD7 O75084 NCS1 Homo sapiens P62166 32296183
种属内
FZD7 O75084 BCL2L13 Homo sapiens Q9BXK5 32296183
种属内
FZD7 O75084 BCL2L13 Homo sapiens Q9BXK5 32296183
种属内
FZD7 O75084 BCL2L13 Homo sapiens Q9BXK5 32296183
种属内
FZD7 O75084 HPCAL1 Homo sapiens P37235 32296183
种属内
FZD7 O75084 HPCAL1 Homo sapiens P37235 32296183
种属内
FZD7 O75084 HPCAL1 Homo sapiens P37235 32296183
种属内
FZD7 O75084 NCALD Homo sapiens P61601 32296183
种属内
FZD7 O75084 NCALD Homo sapiens P61601 32296183
种属内
FZD7 O75084 NCALD Homo sapiens P61601 32296183
种属内
FZD7 O75084 UBQLN2 Homo sapiens Q9UHD9 32296183
种属内
FZD7 O75084 UBQLN2 Homo sapiens Q9UHD9 32296183
种属内
FZD7 O75084 UBQLN2 Homo sapiens Q9UHD9 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FZD7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78730 Frizzled-7 Protein, Human (HEK293, His) O75084 (Q33-L185) ≥95%
HY-P79214 Frizzled-7 Protein, Human (CHO, hFc) O75084/NP_003498 (Q33-L185) ≥95%

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FZD7 VGNC VGNC:99364
Felis catus FZD7 VGNC VGNC:80213
Bos taurus FZD7 VGNC VGNC:29171
Mus musculus FZD7 MGD MGI:108570
Canis familiaris FZD7 VGNC VGNC:57384
Rattus norvegicus FZD7 RGD RGD:2321905
Others FZD7 NCBI