2. Stem Cell/Wnt
  3. Wnt
  4. Fz7-21

Fz7-21  (Synonyms: Ac-LPSDDLEFWCHVMY-NH2)

目录号: HY-P1454 纯度: 98.44%
COA 产品使用指南

摩尔计算器

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) 是一种有效的 FZD7受体 的肽拮抗剂，选择性地结合到 FZD7 CRD 亚类，并改变 CRD 的构象及其脂质结合槽的结构。人和小鼠 FZD7 CRD 的EC50 值分别为 58 和 34 nM。Fz7-21 损害 FZD7 在 Wnt-β-catenin 信号传导中的功能和肠类器官中的干细胞功能。

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Fz7-21 Chemical Structure

Fz7-21 Chemical Structure

CAS No. : 2247635-23-8

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规格 价格 是否有货 数量
1 mg ￥1100
In-stock
5 mg ￥2900
In-stock
10 mg ￥4600
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Fz7-21:

Fz7-21 相关抗体

Top Publications Citing Use of Products

    Fz7-21 purchased from MCE. Usage Cited in: Cell Prolif. 2023 Mar 27;e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) downregulates the expression of the stemness biomarker ΔNp63α in hLESCs.

    Fz7-21 purchased from MCE. Usage Cited in: Cell Prolif. 2023 Mar 27;e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) suppresses hLESC proliferation induced by WNT16b in hLESCs.

    Fz7-21 purchased from MCE. Usage Cited in: Cell Prolif. 2023 Mar 27;e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) decreases the expression of Calcineurin A and NFATC2 in hLESCs.

    Fz7-21 purchased from MCE. Usage Cited in: Cell Prolif. 2023 Mar 27;e13460.  [Abstract]

    Fz7-21 (200 nM; 14 days) inhibits the release of Ca2+ induced by WNT16b in hLESCs.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids[1][2].

    IC50 & Target

    EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)[1]
    体外研究
    (In Vitro)

    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (0-100μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC50 value of 100 nM[1].
    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (1 µM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 value of 50 nM[1].
    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (200 µM; 48 h; LGR5–GFP+ stem cells) disrupts LGR5+ stem cell function[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Fz7-21 相关抗体:
    分子量

    1796.05

    Formula

    C83H114N18O23S2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    Sequence Shortening

    Ac-LPSDDLEFWCHVMY-NH2
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 100 mg/mL (55.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 0.5568 mL 2.7839 mL 5.5678 mL
    5 mM 0.1114 mL 0.5568 mL 1.1136 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Fz7-21 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.5568 mL 2.7839 mL 5.5678 mL 13.9194 mL
    5 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7839 mL
    10 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3919 mL
    15 mM 0.0371 mL 0.1856 mL 0.3712 mL 0.9280 mL
    20 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
    25 mM 0.0223 mL 0.1114 mL 0.2227 mL 0.5568 mL
    30 mM 0.0186 mL 0.0928 mL 0.1856 mL 0.4640 mL
    40 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.3480 mL
    50 mM 0.0111 mL 0.0557 mL 0.1114 mL 0.2784 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fz7-212247635-23-8Ac-LPSDDLEFWCHVMY-NH2WntFZD7conformationlipid-binding grooveFZD7 CRDWnt–β-cateninintestinal organoidsInhibitorinhibitorinhibit

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