2. Gene
  3. Hcn1 - hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 Gene

Hcn1 - hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 84390 | 基因类型: protein coding

关于 Hcn1

功能概要

Enables identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to interferon-beta; maternal behavior; and response to L-glutamate. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study anxiety disorder and mood disorder. Biomarker of complex cortical dysplasia with Other brain malformations; epilepsy (multiple); and meningitis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcn1 基因产物(1)

mRNA Protein Name
NM_053375.2 NP_445827.2 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
19008224 RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
22948144 RGD
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
22948144 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17988239 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interferon-beta IEP
IEP: 通过表达模式推断
23042740 RGD
involved in maternal behavior IEP
IEP: 通过表达模式推断
16820024 RGD
involved in negative regulation of action potential IMP
IMP: 通过突变表型推断
22884333 RGD
involved in positive regulation of cation channel activity IDA
IDA: 通过直接分析推断
20806410 RGD
involved in positive regulation of membrane hyperpolarization IMP
IMP: 通过突变表型推断
30408474 RGD
involved in regulation of membrane depolarization IDA
IDA: 通过直接分析推断
20806410 RGD
involved in regulation of membrane hyperpolarization IMP
IMP: 通过突变表型推断
22884333 RGD
involved in response to L-glutamate IEP
IEP: 通过表达模式推断
20215108 RGD
involved in response to calcium ion IDA
IDA: 通过直接分析推断
19008224 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical dendrite IDA
IDA: 通过直接分析推断
19458150 RGD
located in axon IDA
IDA: 通过直接分析推断
17439493 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
17460082 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11675786 RGD
located in cell surface IDA
IDA: 通过直接分析推断
20215108 RGD
located in dendrite IDA
IDA: 通过直接分析推断
24451387 RGD
located in dendrite membrane IDA
IDA: 通过直接分析推断
23324324 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
17439493 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
24451387 RGD
located in somatodendritic compartment IDA
IDA: 通过直接分析推断
23324324 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-18940 Cilobradine / Phase 2
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13422 Zatebradine hydrochloride Antagonist 99.87% 否
HY-13422A Zatebradine Antagonist 99.27% 否
HY-160505 RO-275 Inhibitor 99.0% 否
HY-W052508 Norquetiapine 99.95% 否
HY-163455 pan-HCN-IN-1 Inhibitor 99.84% 否
HY-108574 CP 339818 hydrochloride Inhibitor 99.61% 否
HY-W052508S Norquetiapine-d8 / 否
HY-114540 CP-339818 Inhibitor / 否
HY-RS06046 HCN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22198 Hcn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28720 Hcn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hcn1 NCBI NCBI:348980
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