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  3. Norquetiapine-d8

Norquetiapine-d8  (Synonyms: 脱烷基喹硫平-d8; N-Desalkylquetiapine-d8)

目录号: HY-W052508S
产品使用指南 技术支持

Norquetiapine-d8 (N-Desalkylquetiapine-d8) 是 Norquetiapine 的氘代物。 Norquetiapine (N-Desalkylauetiapine) 是 Quetiapine (HY-14544) 的代谢物,是一种选择性 HCN1 通道抑制剂,IC50 为 13.9 μM。Norquetiapine 选择性地抑制去甲肾上腺素再摄取,是 5-HT1A (Ki = 45 nM) 受体的部分激动剂,并作为前突触 α2 (Ki = 237 nM)、5-HT2C (Ki = 107 nM) 和 5-HT7 (Ki = 76 nM) 受体的拮抗剂。Norquetiapine 以状态依赖的方式阻断人体心脏钠通道 Nav1.5。Norquetiapine 在 LPS (HY-D1056) 注射的 C57BL/6 小鼠中显示出部分抗炎作用。Norquetiapine 可用于抑郁症和炎症研究。

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Norquetiapine-d<sub>8</sub>

Norquetiapine-d8 Chemical Structure

CAS No. : 1189866-35-0

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Other Forms of Norquetiapine-d8:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC50 of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT1A (Ki = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (Ki = 237 nM), 5-HT2C(Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation[1][2][3][4][5].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

303.45

Formula

C17H9D8N3S

CAS 号
非标记 CAS
中文名称

脱烷基喹硫平-d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Norquetiapine-d8
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HY-W052508S
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