1. Cytoskeleton
  2. Integrin
  3. Gly-Arg-Gly-Asp-Ser (TFA)

Gly-Arg-Gly-Asp-Ser (TFA) 

目录号: HY-P0295A
产品使用指南

Gly-Arg-Gly-Asp-Ser (TFA) 是一种五肽,构成了糖蛋白,骨桥蛋白与细胞的结合域。Gly-Arg-Gly-Asp-Ser (TFA) 与整合素整联蛋白受体 (integrin receptor) αvβ3 和 αvβ5 结合,IC50 估算值为 ∼5 和 ∼6.5 μM。

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Custom Peptide Synthesis

Gly-Arg-Gly-Asp-Ser (TFA) Chemical Structure

Gly-Arg-Gly-Asp-Ser (TFA) Chemical Structure

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Gly-Arg-Gly-Asp-Ser (TFA) 的其他形式现货产品:

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Other Forms of Gly-Arg-Gly-Asp-Ser (TFA):

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Description

Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin[1]. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM[2].

IC50 & Target

IC50: 5 μM (αvβ3), 6.5 μM (αvβ5)[2]

Molecular Weight

604.49

Formula

C₁₉H₃₁F₃N₈O₁₁

Sequence

Gly-Arg-Gly-Asp-Ser

Sequence Shortening

GRGDS

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Gly-Arg-Gly-Asp-Ser (TFA)
目录号:
HY-P0295A
需求量:

Gly-Arg-Gly-Asp-Ser (TFA)

Cat. No.: HY-P0295A