1. Peptides
  2. GR 82334

GR 82334 

目录号: HY-P1193
产品使用指南

GR 82334 是一种有效的、特异性的可逆速激蛋白 NK1 受体 (tachykinin NK1 receptor) 拮抗剂。GR 82334 通过阻断 NK1 受体的作用,抑制大鼠神经肽 P 物质诱导的致敏作用。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

GR 82334 Chemical Structure

GR 82334 Chemical Structure

CAS No. : 129623-01-4

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].

In Vivo

GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)[1].
GR 82334 (10 nM-1 µM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency[2].

Animal Model: 3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2]
Dosage: 10 nM, 100 nM, and 1 µM
Administration: Lntrathecal injection between vertebrae L4 and L5 
Result: Increased heat-induced foot withdrawal latency in mice.
Molecular Weight

1386.55

Formula

C₆₉H₉₁N₁₅O₁₆

CAS No.

129623-01-4

Sequence Shortening

{Glp}ADPNKFY-{Aaa}-LW-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GR 82334GR82334GR-82334Otherstachykinin NK1neuropeptideneurokinin antagonistInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
GR 82334
目录号:
HY-P1193
需求量: