1. GPCR/G Protein Neuronal Signaling
  2. Neurokinin Receptor
  3. GR 87389

GR 87389 是一种有效的 NK2 受体拮抗剂。GR 87389 以竞争性方式拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩。

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Custom Peptide Synthesis

GR 87389 Chemical Structure

GR 87389 Chemical Structure

CAS No. : 141663-86-7

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].

IC50 & Target[1]

NK2

 

体外研究
(In Vitro)

GR 87389 是一种非肽和肽速激肽拮抗剂,对海马、膀胱和十二指肠的 Ki 值分别为 4.0、5.2 和 14 nM[1]
GR 87389 (30-300 nM) 拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

900.07

Formula

C47H65N9O9

CAS 号
Sequence Shortening

{Boc}-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GR 87389
目录号:
HY-P3853
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