2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. GR231118

GR231118  (Synonyms: 1229U91; GW1229)

目录号: HY-P1321
产品使用指南

摩尔计算器

GR231118 是神经肽Y 的 C 末端的类似物，对人神经肽 Y Y 受体具有较强的竞争性和相对选择性拮抗剂，其拮抗剂的 pKi 为10.4。GR231118 是人类神经肽 Y4 受体 (pEC50=8.6; pKi=9.6) 和对人及大鼠神经肽 YY2 和 Y5 受体的弱激动剂。GR231118 对小鼠神经肽 YY6 受体也有较高亲和力 (pKi= 8.8)。

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Custom Peptide Synthesis

GR231118 Chemical Structure

GR231118 Chemical Structure

CAS No. : 158859-98-4

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Other Forms of GR231118:

GR231118 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].

IC50 & Target

NPY Y4 receptor

 

分子量

2352.74

Formula

C110H170N34O24
CAS 号
Sequence Shortening

Sequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1':IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4';Dpr4-Glu2')
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GR231118 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR231118158859-98-41229U91 GW1229GR 231118GR-231118GW1229GW 1229GW-1229Neuropeptide Y ReceptorNPY receptorNeuropeptideantagonistanalogueradioligandC-terminusInhibitorinhibitorinhibit

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